Cytochrome P450 evolution

Gonzalez FJ, Gelboin HV. Human cytochromes P450 evolution and cDNA-directed expression. Environ Health Perspect 1992 98 81-85. 

Nebert, D.W., and McKinnon, R.A., Cytochrome P450 Evolution and functional diversity, Prog. Liver Dis. 12,63-97,1994. 

Gonzalez, F. J. and Gelboin, H. V. (1991) Human cytochromes P450 evolution, catalytic activities and interindividual variations in expression. Prog. Clin. Biol. Res. 372, 11-20. 

Lewis, D.F.V. (1996). Cytochromes P450—Contains a very useful chapter on the evolution of forms of cytochrome P450. 

THE ROLE OF CYTOCHROMES P450 IN BIOSYNTHESIS AND EVOLUTION OF GLUCOSINOLATES... 

Duffy JE, Hay ME (2001) The ecology and evolution of marine consumer-prey interactions. In Bertness MD, Gaines SD, Hay ME (eds) Marine community ecology. Sinauer, Sunderland, pp 131-158 Duisken M, Sandner F, Blomeke B, Hollender J (2005) Metabolism of 1,8-cineole by human cytochrome P450 enzymes identification of a new hydroxylated metabolite. Biochim Biophys Acta 1722 304-311... 

Rozman D, Stromstedt M, Waterman MR. 1996. The three human cytochrome P450 lanosterol 14 alpha-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13 structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family. Arch Biochem Biophys 333 466-474. 

Danielson, P. B. (2002) The cytochrome P450 superfamily biochemistry, evolution and dmg metabolism in humans. Curr. Drug. M. 3, 561-597. 

Nebert DW, Nelson DR, Feyereisen R. Evolution of the cytochrome P450 genes. Xenobiotica 1989 19 1149-1160. 

Finta C, Zaphiropoulos PG. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene 2000 260(l-2) 13-23. 

Classification and Evolution of Cytochrome P450. The techniques of molecular... 

Comparative biochemistry. Some researchers believe that the proper role of comparative biochemistry is to put evolution on a molecular basis, and that detoxication enzymes, like other enzymes, are suitable subjects for study. Xenobiotic-metabolizing enzymes were probably essential in the early stages of animal evolution because secondary plant products, even those of low toxicity, are frequently lipophilic and as a consequence would, in the absence of such enzymes, accumulate in lipid membranes and lipid depots. The evolution of cytochrome P450 isoforms, with more than 2000 isoform cDNA sequences known, is proving a useful tool for the study of biochemical evolution. 

Joo H. LinZ. Arnold F. H. Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Nature 1999, 399, 670-673. 

Heim HM, Meyer UA. Evolution of a high polymorphic human cytochrome P450 gene cluster CYP2D6. Genomics 1992 14 49-58. 

Marez D, Legrand M, Sabbagh N, et al. Polymorphism of the cytochrome P450 C YP2D6 gene in a European population characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 1997 7 193-202. 

These screens have been used to direct the evolution of cytochrome P450 BM-3, a soluble enzyme from Bacillus megaterium that contains its reductase and hydroxylase domains on a single polypeptide chain. P450 BM-3 primarily catalyzes the hydroxylation of fatty acids ( 12 to 18 carbons long) at the a>-1, a>-2, and m-3 positions, but also... 

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