Drug interactions cytochrome P450-based

Examples of cytochrome P450-based drug interactions... 

Dickins, M., Galetin, A. and Proctor, N. (2007) Modelling and simulation of pharmacokinetic aspects of cytochrome P450-based metabolic dmd-drug interactions, in Comprehensive Medicinal Chemistry II, vol. 5 (eds J.B. Taylor and D.J. Triggle), Elsevier Ltd, Oxford,... 

Tang C, Lin JH, Lu AYH. Metabolism-based drug-drug interactions what determines individual variability in cytochrome P450 induction Drug Met Disp. 2005 33 603-613. 

Jones, B. C., Ciark, S. E., Human cytochromes P450 and their role in metabolism based drug-drug interactions, in Drug-Drug Interactions. Rodrigues, A. D. (ed.), 2001, Chapter 3, 55-88. Marcel Dekker Inc. New York. 

Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions a prospective based on conformational dynamics. Chemical Research in Toxicology, 14 (4), 338-347. 

Obach, R.S., Walsky, R.L. and Venkatakrishnan, K. (2007) Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions. Drug Metabolism and Disposition, 35 (2), 246—255. 

Kalgutkar, A.S., Obach, R.S. and Maurer, T.S. (2007) Mechanism-based inactivation of cytochrome P450 enzymes chemical mechanisms, structure-activily relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Current Drug Metabolism, 8, 407—447. 

Venkatakrishnan, K. and Obach, R.S. (2007) Drug-drug interactions via mechanism-based cytochrome P450 inactivation points to consider for risk assessment from in vitro data and dinical pharmacologic evaluation. Current Drug Metabolism, 8, 449-462. 

Acceptable drug metabolism and interaction profiles based on microsomal and recombinantly expressed cytochrome P450 isoenzyme studies Recent addition Toxicogenomic data for early assessment of alteration in expression of RNA transcripts (and therefore proteins) related to toxic responses so that modification of safer and more potent variants of NME could be made and identified early... 

Jones DR, Hall SD. Mechanism based inhibition of cytochrome P450 in vitro kinetics and in vitro-in vivo correlations. In Rodrigues AD, ed. Drug-Drug Interactions From Basic Pharmacokinetics Concepts to Marketing Issues. New York, NY Marcel Dekker, 2001. 

Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions... 

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