Cytisin

Baptisia australis, B. tinctoria R. Br. and other species. Cytisine. A... 

C. stenopetalus belong to group (c) and contain up to 0-4 per cent, of alkaloids mainly cytisine and methylcytisine with traces of anagyrine in some specimens of the second species. C. monspes-sulanus also belongs to group (c) and contains 0-9 per cent, of alkaloids chiefly methylcytisine with some cytisine and a new alkaloid monspessulanine (p. 146), probably of the lupanine group. (1946). 

Genista celnensis. Seeds contain cytisine plants contain retamine,... 

From cytisine COOH. CHMe. CHj. CHMe. COOH... 

Constitution. On electrolytic reduction cytisine yields tetrahydrode-oxycytisine, C44H20N2, an alkaline oil, b.p. 270°, yielding a crystalline hydrochloride, B. HCl, m.p. 282°, [aju — 10-25°. With phosphorus and hydriodic acid cytisine furnishes ammonia and cytisoline, C41H44ON,... 

In 1931 Ing pointed out that formula (II) and (III) do not contain methyl or potential methyl groups in j ositions 6 and 8 which they occupy in cytisoline. Further, a partially reduced quinoline ought to oxidise easily to a benzenecarboxylic acid and so far the only simple oxidation, products recorded from cytisine were ammonia, oxalic acid and isovaleric acid. Distillation of cytisine with zinc dust or soda-lime yields pyrrole and pyridine, but no quinoline. On these grounds Ing suggested that cytisine should be formulated without a quinoline nucleus, and that the reactions which indicate the presence of an aromatic nucleus in the alkaloid can be accounted for by an a-pyridone ring. This a-pyridone nucleus can... 

Cytisine. This base belongs to the same pharmacological group as nicotine.It is a powerful poison causing nausea, convulsions and death by failure of respiration. The nicotine-like action is shared by A -methyl-cytisine but the latter, according to Scott and Chen, who have made a detailed study of its action, is weaker and has about one-fortieth the toxicity of nicotine. 

Vlex euTopaeus, 118, 140 Ulexine (cytisine), 140, 142 Umbellatine, 329, 340, 345 Ungernia sewertzooii imgemine, 406 Upas tree, 554... 

Lupanine, Sparteine, Anagyrine, Cytisine, Matrine and Associated Bases. . . . . . . -. ... 

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