Alkaloids cytisine

More recently, infrared data have found further application in conformational studies of complex quinolizine derivatives, such as the previously mentioned alkaloid cytisine 9. Comparison of experimental values for the and t co) frequencies with the theoretical values obtained from semi-empirical calculations for... 

Eurther, a compound collection based on the scaffold of the natural product Euranodictin (Eigure 9.12D) revealed a previously uncharacterized inhibitor class for the protein tyrosine phosphatases PTPIB and Shp-2." A compound collection which embodies the underlying scaffold structure of alkaloid cytisine and related natural products (Figure 9.12E) revealed the first inhibitor class of the vascular endothelial protein tyrosine phosphatase (VEPTP) at a hit rate of 1.57% as well as a completely new class of inhibitors for protein tyrosine phosphatase-IB and the phosphatase Shp-2. These two enzymes are targets for the treatment of the metabolic syndrome and diabetes as well as cancer respectively. In these cases the hit rates were ca. 0.3 to 0.4%. The screens revealed selective inhibitors for the proteins." ... 

The poisonous part of the plant is above all the seeds due to the occurrence of the alkaloid cytisine 2-10 seeds can give symptoms of poisoning in children as can 3-4 pods for an adult. Within 15 minutes to a few... 

Tschirsch, C, Lj. Kraus Goldregen-Alkaloid Cytisin , Dtsch. Apoth. Ztg. 131, 1876-1878, (1991)... 

Laburnum anagyroides seeds, flowers, bark contain the highly toxic alkaloid, cytisine. Produce dilated pupils, gastro-intestinal upset and vomiting, weakness, inco-ordination, asphyxia, death. Rabbits and hares are apparently unaffected. 

Comparison of synthetic strategies and routes of total s5mthesis of the lupin alkaloid cytisine 07T1885. 

Enantioselective deprotonation of tertiary dimethylphosphines 143 can be achieved with s-BuLi in the presence of accessible and cheap derivatives of alkaloid ( )-cytisine 148. The derivatives of cytisine 148 are useful sparteine... 

Documented effects Used as an expectorant and vermifuge (Khalmatov 1964). The alkaloid cytisine is used to prepare a 0.15% solution, called cytion, which is used to increase respiration in cases of respiratory standstill, such as during operations and traumas, from infectious diseases, shocks, various intoxication (such as poisoning by carbon oxide, prussic acid, and narcotics), asphyxia of newborns, and others. Pachycarpine increases uterine contractility and is used in obstetrical practice to stimulate contractions for weak labors, and also to stop bleeding during the post-natal period (Mashkovskii 1984). 

Phytochemistry The aboveground parts contain alkaloids (cytisine, thermopsine, N-methylcytisine, anagyrine, and sparteine Plant Resources of the USSR 1987). 

A diversity of thiolactams has been prepared from the corresponding lactams by use of LR or of the modified reagent (13). Monobactam analogs, e.g., the weakly antibacterial -thiolactam (93), have been prepared by thionation of suitably protected optically active /3-lactams with LR or Davy s reagent (2,4-bis (methylthio)-l,3,2,4-dithiadiphosphetane disulfide), deprotection and subsequent introduction of the side chain. Very recently, an efficient solid-phase synthesis of 1,3,4-trisubstituted /3-thiolactams has been described. The y-thiolactam (94) has been prepared as an intermediate for the synthesis of analogs of the acetylcholinesterase inhibitor huperzine B. Transformation of the quinoline alkaloid cytisine into its thio analog (95) enhanced its biological activity. ... 

Contains alkaloids lobeline, lobeHdirte Toxic principle is coniine and related alkaloids Contains the quinolizidine alkaloid cytisine Contains cytisine, similar to Cymnocladus... 

Nicotine boldine and other aporphine alkaloids C-toxiferine coniine and other piperidine alkaloids cytisine and other quinohzidine alkaloids epibatidine tubocurarine Berbamine, berberine, and other isoquinoline alkaloids cinchonidine and other quinoline alkaloids corynanthine, yohimbine, and other indole alkaloids emetine ephedrine ergometiine and related ergot alkaloids Ergocornine and related ergot alkaloids bulbocapnine and related aporphine alkaloids anisocycline, stylopine, and related protoberberine alkaloids salsolinol and related isoquinohnes BicuculUne, cryptopine, hydrastine, and related isoquinoline alkaloids securinine harmaline and related beta-carboline alkaloids Corymine, strychnine, and related indole alkaloids Histrionicotoxin and related piperidines ibogaine and related indole alkaloids nuciferine and related aporphine alkaloids... 

O Brien convincingly showed that diamine 71 could be utilized as a (+)-spar-teine surrogate, thus leading to enantiomeric products (Scheme 13.12) [58], Diamine 71 could readily be prepared from the naturally available alkaloid cytisine (73, Scheme 13.13), which could be isolated from Laburnum anagyr-oides seeds (available in kg quantities) through a simple and high-yielding extraction procedure. 

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