Cytidine 5 - , monohydrate

Rosenberg JM, Seeman NC, Day RO, Rich A (1976) RNA double-helical fragment at atomic resolution. II. The crystal structure of sodium guanylyl-3, 5 -cytidine monohydrate. J Mol Biol 104 145-167... 

C9H12N3OsP Co h2o Cytidine 5 -[cobalt(II) phosphate], monohydrate CYTPCO10 38 505... 

C9Hi2N3OsP Zn H20 Cytidine 5 -(zinc phosphate), monohydrate CYTPZN 37 435... 

X-ray crystal results on cytosine itself10 -13 (anhydrous and monohydrate), its complexes with different partners,15-20 cytidine,21 and cytidine 2, 3 -cyclic phosphate22 all indicate its existence in the lactam-amine form (2). In a number of crystals the cytosine ring is protonated, invariably at N-3.23-32 In cytosine 5-acetic acid33 half of the molecules... 

Cyclic Trimer Configuration. The a-cytidine [ACYTID] crystal structure contains two cyclic trimer configurations (Fig. 17.32). In one, N(H)H is engaged in a three-center bond, the other is a homodromic cycle stabilized by a- and w-cooperativity. A comparable situation is found in the crystal structure of a-pseudouridine monohydrate [APSURD] (Fig. 17.13). The glycosyl link is to uracil C(6) instead of N(l), and therefore the N(1)H group is free to donate a hydrogen bond in a homodromic cycle. 

If the crystal structures and hydrogen-bonding patterns of uridine and thymidine and their simpler derivatives are compared with those of cytidine, it becomes obvious that the -NH2 functional group has a characteristic influence. The nucleosides without the -NH2 groups have less than average hydrated crystals, although the one nucleotide represented, uridine-3 -monophosphate, crystallizes as a monohydrate. 

DEOXYRIBONUCLEOSIDE CYTOSINE see DAQ850 DEOXYRIBOSE CYTIDINE see DAQ850 DEOXYTETRARIC ACID see MANOOO 4-DEOXYTETRONIC ACID see BOVOOO P-DEOXYTHIOGUANOSINE see TFJ250 P-2 -DEOXY-6-THIOGUANOSINE MONOHYDRATE see TFJ250... 

Anhydro-2, 3 -O-isopropylideneadenosine iodide Adenosine 3, 5 -phosphate, P,0-ethyl ester, monohydrate N -[(Carboxymethyl)aminocarbonyl]adenosine (Glycylglycinato)copper(II)cytidine, dihydrate... 

C2 2Hft 4N10O18 2Pt2, Di-M (5 cytidine monophosphate)-bis(ethylenedi-amineplatinum) dihydrate, 43B, 1325 C23H29N5O7Zn, (Ethylenediamine)zinc(II) benzohydroxamate benzohydro-xamic acid monohydrate, 40B, 816... 

C9H16CdN30ioPf Aquo(cytidine-5 phosphato)cadmium(II) monohydrate, 44B, 988... 

Nucleoades and their Analogues and Derivatives Thereof. - 5-Acetyi-l-(3,5-0-isopropylidene-a-D-xylofuranosyl)uracil monohydrate has the furanose ring in a C2 -endo, C3 -endo conformation and a glycosidic torsion angle of —31°. X-ray structures of adenosine, cytidine, uridine and thymidine were interpreted in terms of C-H-- 0 interactions, while guanosine lacks these interactions. Another structural analysis of cytidine was reported and studies of crystal... 

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