Cystic fibrosis macrophages

There is abundant evidence that a diverse array of pro-teinases, particularly those of macrophage or leucocyte origin, have a fundamental role in the injury processes associated with diseases such as ai-antitrypsin deficiency, smoking-related emphysema, cystic fibrosis, bronchiectasis, bronchitis and other respiratory syndromes (Karlinsky and Snider, 1978 Stockley, 1983 Senior and Campbell, 1983 Surer etal., 1984 Janoff, 1985 Snider etal., 1991). However, there has been little exploration of their potential involvement in other airway disorders that have an inflammatory cell aetiology, such as certain types of specialized fibrotic disorders including chronic severe asthma. This is particularly true for the matrix metalloproteinases (MMPs), despite the expectation from their individual substrate specificities (Emonard and... 

While it is abundantly clear that pro-inflammatory cytokines and chemokines are present in elevated levels in the airways of patients with cystic fibrosis, the pattern of expression of the anti-inflammatory cytokines IL-10 and TGFP is less consistently apparent. IL-10 may be particularly important in the protection of the airways against inflammation. Originally shown to be produced in macrophages and... 

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C. M. Lloyd et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-gamma. 287 41651-41666. 

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