Cystadenocarcinoma

FIGURE 9.1. Sialosyl-Tn antigen staining in the ovarian serous cystadenocarcinoma, usingTKH-2 antibody. Only apical parts of the cytoplasm are stained. Courtesy of Kanji Ryuko. For a color representation of this figure, see Plate 4F facing page 99. 

Fig. 5. Immunohistochemical expression of (a) hK14 by the ovarian surface epithelium (polyclonal antibody), (b) hK14 by a cystadenocarcinoma of the ovary (polyclonal antibody),...

Devaney, K., Goodman, Z.D., Ishak, K.G. Hepatobiliary cystadenoma and cystadenocarcinoma. A light microsopig and immunhistochemical study of 70 patients. Amer. X. Surg. Pathol. 1994 18 1078-1091... 

Bast and associates developed the MAh OC 125 using a cell line (OVCA 433) from a patient with a serous papillary cystadenocarcinoma of the ovary. The OC 125 clone was selected for its reactivity with the OVCA 433 cell line and for its lack of reactivity with a B-lymphocyte line from the same patient. 

In one patient with serious cystadenocarcinoma, stage lib, it was possible to monitor Mn-SOD levels on nine occasions over 30 months (Fig. 23). After surgical cytoreduction and chemotherapy with a combination of cyclophosphamide, adriamycin, and cisplatin, i.e., CAP, Mn-SOD levels decreased from 266 to 66 ng/ml. Laparotomy failed to reveal residual tumor, and treatment was then continued with cisplatin. After 2 years the Mn-SOD level rose to 166.5 ng/ml, with CA 125 rising to 150 U/ml. At this time, abdominal computerized tomography (CT) revealed a small pelvic mass and ascites. Thus, increases in Mn-SOD and CA 125 were observed upon recurrence of disease. 

Immunohistochemical studies of Mn-SOD were done on ovarian cancer tissues. Of four ovarian serous cystadenocarcinoma tissues tested, two stained positively with the antibody used for the ELISA experiments. Antibody localization of Mn-SOD in the tissue is illustrated in Fig. 24. Control sections incubated with a monoclonal antihuman IgG and then stained with fluorescein-conjugated horse antimouse immunoglobulin failed to show uptake of antibody. No reactivity with... 

Fia. 23. Serum Mn-SOD levels during the course of treatment of one patient with stage lib serous cystadenocarcinoma (CAP, cyclophosphamide, adriamycin, and cisplatin treatments SLO, second-look operation). 

Fig. 24. A section of serous cystadenocarcinoma, stained with monoclonal antibody to Mn-SOD. Bright staining is seen in the cytoplasm of the carcinoma cells. Left panel, xlOOO magnification right panel, xlOO magnification.

H2. Heyd, J., Livni, N Herbet, D., Mor-Yosef, S and Glaser, B., Gastrin producing ovarian cystadenocarcinoma Sensitivity to secretion and SMS 201-995. Gastroenterology 97, 464-467 (1989). 

A relatively newly described entity that has gone under several different names is low-grade cribriform cystadenocarcinoma. It has been also called low-grade salivary duct carcinoma and low-grade intraductal carci-... 

The immunohistochemical staining profile of low-grade cystadenocarcinoma can be helpful in the workup of these rare lesions. The lesion will be strongly and diffusely positive for S-100 (Fig. 9.29). Importantly, a myoepithelial cell layer will be preserved around the periphery of the nests of tumor cells. It has been claimed that this tumor should be considered to be an in situ tumor because a myoepithelial layer is preserved (Fig. 

Some low-grade cribriform cystadenocarcinomas have been reported in conjunction with salivary duct carcinoma. Others have been described as having minimal stromal invasive components and these areas do lose their myoepithelial cells. However, in pure low-grade cribriform cystadenocarcinoma lesions, the prognosis is excellent. No recurrences were seen in two separate series, with a mean follow-up of 32 months in one series and 2 to 12 years in the second series. ... 

Low-grade cribriform cystadenocarcinoma is a rare tumor that grows in a variety of patterns. 

Carcinoid tumor, atypical, lung 100 Cystadenocarcinoma, ovarian 2... 

Biliary cystadenomas and cystadenocarcinomas have an immunohistochemical profile similar to pancreatobiliary cystadenomas and cystadenocarcinomas." The epithelium typically shows staining for CK7, CK20, AE1/AE3, CEA, CA 19-9, and CA125." Ovarian-type stroma may be present and may show staining for pro-... 

Nishihara K, Katsumoto F, Kurokawa Y, et al. Anaplastic carcinoma showing rhabdoid features combined with mucinous cystadenocarcinoma of the pancreas. Arch Pathol Lab Med. 1997 121 1104-1107. 

Thompson LD, Becker RC, Przygodzki RM, et al. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas a clinicopathologic study of 130 cases. Am J Surg Pathol. 1999 23 1-16. 

Albores-Saavedra J, Nadji M, Henson DE, et al. Entero-endo-crine cell differentiation in carcinomas of the gallbladder and mucinous cystadenocarcinomas of the pancreas. Pathol Res Pract. 1988 183 169-175. 

Albores-Saavedra J, Angeles-Angeles A, Nadji M, et aL Mucinous cystadenocarcinoma of the pancreas. Morphologic and immimocytochemical observations. Am J Surg Pathol. 1987 11 11-20. 

Weihing RR, Shintaku IP, Geller SA, Petrovic LM. Hepatobiliary and pancreatic mucinous cystadenocarcinomas with mesenchymal stroma analysis of estrogen receptors/progesterone receptors and expression of tumor-associated antigens. Mod Pathol. 1997 10 372-379. 

Siren J, Karkkainen P, Luukkonen P, et al. A case report of biliary cystadenoma and cystadenocarcinoma. Hepatogastroenterology. 1998 45 83-89. 

Mucoceles of the appendix are relatively rare lesions. They vary considerably in size. Giant lesions up to 25 cm can be present. The large lesions are most often caused by mucus-producing tumours such as cystad-enoma or cystadenocarcinoma. Later, they can rupture and produce a Pseudomyxoma peritoneii. Small non-neoplastic lesions are found incidentally during imaging. 

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