Cymbastela

Koenig GM, Wright AD, Angerhofer CK. (1996) Novel potent antimalarial diterpene isocyanates, isothiocyanates, and isonitrile from tropical marine sponge Cymbastela hooperi. J Org Chem 61 3259-3267. 

Kdnig, G.M. Wright, A.D. (1997) New and unusual sesquiterpenes from the tropical sponge Cymbastela hooperi. J. Org. Chem., 62, 837-40. 

A sesquiterpene thiocyanate, cavemothiocyanate (269) was isolated from Acanthella cf. cavernosa and the structure was elucidated on the basis of spectral data. The nudibranch Phyllidia ocellata also contained cavemothiocyanate [270]. Acanthene B (270) is a sesquiterpene isothiocyanate isolated from a British Columbian Acanthella sp. [271]. The sesquiterpene thiol, T-cadinthiol (271) was isolated from Cymbastela hooperi from Kelso Reef on the Great Barrier Reef [272]. A sesquiterpene isothiocyanate that displayed modest in vitro antimalarial activity, (-)-9-isothiocyanatopupukeanane (272) was isolated from an Axinyssa sp. from the Great Barrier Reef [273]. Great Barrier Reef samples of A. cavernosa contained 10-isothiocyanatocadin-4-ene (273) [274],... 

Cymbastela hooperi from the Great Barrier Reef contained four diterpene isothiocyanates (292-295) amongst other diterpenes [285]. An amphilectene isonitrile (296) was isolated from a Caribbean Cribochalina sp. [286]. 

The sterol sulfate, halistanol disulfate B (544) was isolated from a South African Pachastrella sp. The structure and stereochemistry of compound 544 were established mainly by interpretation of spectral data. Halistanol disulfate B (544) was active in the endothelin converting enzyme (ECE) assay at a micromolar concentration [451]. Three sterol trisulfates (545-547) have been isolated from the sponges Trachyopsis halichondrioides and Cymbastela coralliophila [452]. 

Coleman JE, de Silva ED, Kong F, Andersen RJ, Allen TM (1995) Cytotoxic Peptides from the Marine Sponge Cymbastela sp. Tetrahedron 51 10653... 

Coleman JE, Van Soest R, Andersen RJ (1999) New Geodiamolides from the Sponge Cymbastela sp. Collected in Papua New Guinea. J Nat Prod 62 1137... 

Hong TW, Jhnenez DR, Molinski TF (1998) Agelastatins C and D, New Pentacyclic Bromopyrroles from the Sponge Cymbastela sp., and Potent Arthropod Toxicity of (-)-Agelastatin A. J Nat Prod 61 158... 

Axinellidae Acanthella Auletta Axinella Cymbastela Dragmacidon Homaxinella Phakellia Phycopsis Pseudaxinella Ptilocaulis Stylotella Teichaxinella... 

This class includes only agelastatins A-D (60-65), a family of tetracyclic oroidin derivatives isolated from Agelas dendromorpha [92,93] and Cymbastela sp. [94]. The absolute configuration of these molecules was deduced through the application of exciton-coupling techniques [93]. 

Fig. (3) Representative antimalarial diterpenoids isolated from the marine sponge Cymbastela hooperi...

Hemiasterlin, a tripeptide isolated from several marine sponges (HemiastereUa minor, Auletta sp., Cymbastela sp., Siphonochalina sp.) exhibiting potent cytotoxicity against a variety of cancer cell lines in vitro via a tubulin antimitotic mechanism. Its relatively simple structure allows structural modifications to obtain analogues with high potency such as taltobulin (HTI-286 also known as SPAllO), which show more potent in-vitro cytotoxicity and antimitotic ac-... 

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