Cymbastela hooperi

Koenig GM, Wright AD, Angerhofer CK. (1996) Novel potent antimalarial diterpene isocyanates, isothiocyanates, and isonitrile from tropical marine sponge Cymbastela hooperi. J Org Chem 61 3259-3267. 

Kdnig, G.M. Wright, A.D. (1997) New and unusual sesquiterpenes from the tropical sponge Cymbastela hooperi. J. Org. Chem., 62, 837-40. 

A sesquiterpene thiocyanate, cavemothiocyanate (269) was isolated from Acanthella cf. cavernosa and the structure was elucidated on the basis of spectral data. The nudibranch Phyllidia ocellata also contained cavemothiocyanate [270]. Acanthene B (270) is a sesquiterpene isothiocyanate isolated from a British Columbian Acanthella sp. [271]. The sesquiterpene thiol, T-cadinthiol (271) was isolated from Cymbastela hooperi from Kelso Reef on the Great Barrier Reef [272]. A sesquiterpene isothiocyanate that displayed modest in vitro antimalarial activity, (-)-9-isothiocyanatopupukeanane (272) was isolated from an Axinyssa sp. from the Great Barrier Reef [273]. Great Barrier Reef samples of A. cavernosa contained 10-isothiocyanatocadin-4-ene (273) [274],... 

Cymbastela hooperi from the Great Barrier Reef contained four diterpene isothiocyanates (292-295) amongst other diterpenes [285]. An amphilectene isonitrile (296) was isolated from a Caribbean Cribochalina sp. [286]. 

Fig. (3) Representative antimalarial diterpenoids isolated from the marine sponge Cymbastela hooperi...

Kdsoene Cymbastela hooperi Konig and Wright, 1997 Nabeta et al., 1999 Mehta and Srinivas, 2001... 

Wright, A.D. and Lang-Unasch, N. (2009) Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro. J. Nat. Prod., 72, 492-495. 

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