Halistanol disulfate

The sterol sulfate, halistanol disulfate B (544) was isolated from a South African Pachastrella sp. The structure and stereochemistry of compound 544 were established mainly by interpretation of spectral data. Halistanol disulfate B (544) was active in the endothelin converting enzyme (ECE) assay at a micromolar concentration [451]. Three sterol trisulfates (545-547) have been isolated from the sponges Trachyopsis halichondrioides and Cymbastela coralliophila [452]. 

Halistanol disulfate B, isolated from Pachastrella sp. has no sulfate in 6a (Patil et al, 1996a). Figure 1934 Examples of trisulfated stanols. 

Patil, A.D., Freyer, A.J., Breen, A., Carte, B., and Johnson, R.K. (1996a) Halistanol disulfate B, a novel sulfated sterol from the sponge Pachastrella sp. inhibitor of endothelin converting enzyme. J. Nat. Prod., 59, 606-608. 

A sterol disulfate (534) and a sterol trisulfate (535), both closely related to halistanol, have been found in a species of Halichondria [447] and in Trachyopsis halichondrioides [448] respectively. 

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