Cyclohexylamine Cyclamate calcium

Hydroxyprogesterone caproate Cyclohexylacetone Droprenilamine HCl Propylhexedrine Cyclohexylamine Clorexolone Cyclamate calcium 1 -Cyclohexylamino-2-propanol Hexylcaine HCl Cyclohexyl bromide Cetiedll... 

Before a 1/1 /70 FDA ban (rescission proposed in early 1990), cyclamate noncaloric sweeteners were the major derivatives driving cycloliexylamine production. The cyclohexylsulfamic acid sodium salt (39) [139-05-9J and mote thermally stable calcium cyclohexylsulfamic acid (40) [139-06-1] salts were prepared from high purity cyclohexylamine by, among other routes, a reaction cycle with sulfamic acid. 

Cyclamate. Group name for synthetic, nonnutritive sweeteners derived from cyclohexylamine or cyclamic acid. The senes includes sodium, potassium, and calcium cydamates. Cyclamates occur as white crystals, or as white crystalline powders. They are odorless and in dilute solution are about 30 times as sweet as sucrose. The purity of commercially available compounds is approximately 98%. 

Discovered in 1937 and patented in 1940, cyclamate is a derivative of cyclohexylamine, specifically, cyclohexane sulfonic acid. The sodium salt form is normally used, but the calcium salt may be substituted in low-sodium diets. See structural formulas below. 

Cyclamate is produced by reacting cyclohexylamine with sulfonating agents, followed by reactions with sodium or calcium hydroxides to produce cyclamates and free cyclohexylamine as follows ... 

Another application of cyclohexylamine is in the manufacture of sodium and calcium cyclohexylsulfamates, used as sweeteners. Cyclohexylamine is converted with SO3 in the presence of an excess of a salt-forming tertiary amine. Subsequent reaction of the amine salt with sodium hydroxide yields sodium cyclohexylsulfa-mate (sodium cyclamate). The calcium salt is produced analogously using calcium hydroxide. 

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