CYCLOHEXANOL, 2-PHENYL,

Cyclohexanol, 2-phenyl-, (1S-trans)- and Cyclohexanol, 2-phenyl-, (1R-lrans)- ... 

Phenyl benzoate Benzoic acid, phenyl ester (93-99-2), 69, 73 PHENYLCYCLOHEXANOL, (+)-(1 S,2R)-trans-2 CYCLOHEXANOL, 2-PHENYL-, (1S-trans)- (34281-92-0), 69, 1... 

Propanol, 2-methyl-l-propa-nol, cyclohexanol, phenyl-methanol AI2 O3 130—240 117... 

Amyl alcohol Cyclohexanol Phenyl ethyl alcohol... 

Likewise, thermolysis of 4-azidophenyl methyl ketone in methanol yields 5-acetyl-2-methoxy-3//-azepine (60%), compared to only an 8% yield from the photolytic reaction.78 119 The thermolysis of phenyl azide in refluxing cyclohexanol yields no 3H-azepine, only diphenyl-diazene (10%) and aniline (30%).74 In contrast, thermolysis of methyl 2-azidobenzoate in cyclohexanol furnishes a mixture of methyl 2-(cyclohexyloxy)-3//-azepine-3-carboxylate (20 % bp 127°C/0.1 Torr) and methyl 2-aminobenzoate (60%). Thermolysis of the azido ester in methanol under nitrogen in an autoclave at 150 C yields a 7 10 mixture (by 1HNMR spectroscopy) of the amino ester and methyl 2-methoxy-3//-azepine-3-carboxylate, which proved to be difficult to separate, and much tar.74 The acidic medium179 is probably responsible for the failure of methyl 2-azidoberjzoate to yield a 3//-azepine when thermolyzed in 3-methoxyphenol aniline (40%) is the major product.74... 

The formation of ethers such as 1806 by EtsSiH 84b can also be catalyzed by trityl perchlorate to convert, e.g., benzaldehyde in 84% yield into dibenzyl ether 1817 [48]. The combination of methyl phenethyl ketone 1813 with O-silylated 3-phenyl-n-pro-panol 1818, in the presence of trityl perchlorate, leads to the mixed ether 1819 in 68% yield [48] (Scheme 12.15). Instead of trityl perchlorate, the combination of trityl chloride with MesSiH 84a or EtsSiH 84b and sodium tetrakis[3,5-bis-(trifluoro-methyl)phenyl]borane as catalyst reduces carbonyl groups to ethers or olefins [49]. Employing TMSOTf 20 as catalyst gives very high yields of ethers. Thus benzaldehyde reacts with O-silylated allyl alcohol or O-silylated cyclohexanol to give the... 

Baba, A., Yamamoto, T., Yamamoto, H., Suzuki, T., and Moroji, T., Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl-4-(l-piperidinyl) cyclohexanol, on [3H]N-(l-[2-thie-nyl]cyclohexyl)-3,4-piperidine([3H TPC) binding and [3H] dopamine uptake in the rat brain, Neurosci. Lett., 182, 119, 1994. 

A" 0-Butenolide, 46, 22 /-Butyl alcohol, in synthesis of phenyl /-butyl ether, 45, 89 reaction with sodium cyanate and trifluoroacetic acid, 48, 32 /-Butyl azidoacctatc, 46, 47 hydrogenation of, 45, 47 /-Butyl carbamate, 48,32 /-Butyl chloroacetate, reaction with sodium azide, 45, 47 /ra S-4-/-BuTYI,CYCLOHEXANOL, 47,16... 

A further attempt has been made to develop a predictive model for chirality transfer achieved through alkylation reactions of ester enolates which feature chiral auxiliaries. " Hippurate esters (30) derived from (lI , 25 )-trani-2-(p-substituted phenyl)cyclohexanols were found, on reaction with benzyl bromide, to give (31) with predominantly the S configuration at the alkylation centre but with no correlation between the degree of stereoselectivity (20-98%) and the electron density on the aromatic ring. 

AI3-00040, see Cyclohexanol AI3-00041, see Cyclohexanone AI3-00045, see Diacetone alcohol AI3-00046, see Isophorone AI3-00050, see 1,4-Dichlorobenzene AI3-00052, see Trichloroethylene AI3-00053, see 1,2-Dichlorobenzene AI3-00054, see Acrylonitrile AI3-00072, see Hydroquinone AI3-00075, see p-Chloro-rrr-cresol AI3-00078, see 2,4-Dichlorophenol AI3-00085, see 1-Naphthylamine AI3-00100, see Nitroethane AI3-00105, see Anthracene AI3-00109, see 2-Nitropropane AI3-00111, see Nitromethane AI3-00118, see ferf-Butylbenzene AI3-00119, see Butylbenzene AI3-00121, see sec-Butylbenzene AI3-00124, see 4-Aminobiphenyl AI3-00128, see Acenaphthene AI3-00134, see Pentachlorophenol AI3-00137, see 2-Methylphenol AI3-00140, see Benzidine AI3-00142, see 2,4,6-Trichlorophenol AI3-00150, see 4-Methylphenol AI3-00154, see 4,6-Dinitro-o-cresol AI3-00262, see Dimethyl phthalate AI3-00278, see Naphthalene AI3-00283, see Di-rj-butyl phthalate AI3-00327, see Acetonitrile AI3-00329, see Diethyl phthalate AI3-00399, see Tributyl phosphate AI3-00404, see Ethyl acetate AI3-00405, see 1-Butanol AI3-00406, see Butyl acetate AI3-00407, see Ethyl formate AI3-00408, see Methyl formate AI3-00409, see Methanol AI3-00520, see Tri-ocresyl phosphate AI3-00576, see Isoamyl acetate AI3-00633, see Hexachloroethane AI3-00635, see 4-Nitrobiphenyl AI3-00698, see IV-Nitrosodiphenylamine AI3-00710, see p-Phenylenediamine AI3-00749, see Phenyl ether AI3-00790, see Phenanthrene AI3-00808, see Benzene AI3-00867, see Chrysene AI3-00987, see Thiram AI3-01021, see 4-Chlorophenyl phenyl ether AI3-01055, see 1.4-Dioxane AI3-01171, see Furfuryl alcohol AI3-01229, see 4-Methyl-2-pentanone AI3-01230, see 2-Heptanone AI3-01231, see Morpholine AI3-01236, see 2-Ethoxyethanol AI3-01238, see Acetone AI3-01239, see Nitrobenzene AI3-01240, see I idine AI3-01256, see Decahydronaphthalene AI3-01288, see ferf-Butyl alcohol AI3-01445, see Bis(2-chloroethoxy)methane AI3-01501, see 2,4-Toluene diisocyanate AI3-01506, see p,p -DDT AI3-01535, see 2,4-Dinitrophenol AI3-01537, see 2-Chloronaphthalene... 

Figure 8. Sol fraction of the PPT-MDI networks with added monofunctional component (cyclohexanol or phenyl Isocyanate keeping rn = 1. for <1, = [OHJppx/XlOH], for >1 =...

Lipase Catalyzed Kinetic Resolution of Alcohols via Chloroacetate Esters (-)-(lR,2S)-trans-2-Phenylcyclohexano1 and (+)-(lS,2R)-trans-2-Phenyl cyclohexanol... 

A second batch of product was obtained by concentration ctnd recrystallization of the mother liquor to provide another 1.89 g (4.4%) of (-)-(1R,2S)-trans-2-phenyl-1-cyclohexanol of a slightly lower enantiomeric purity (98.6% ee). 

Information concerning the chemistry of meso-ionic 3-alkyl- and 3-aryl-l,2,3,4-oxatriazol-5-ones (271) is limited, but further investigation may well be encouraged by reports of pronounced hypotensive activity. 3-Cyclohexyl-1,2,3,4-oxatriazol-5-one (271, R = cyclohexyl) is resistant to attack by dilute mineral acid, but warm concentrated sulfuric acid gives cyclohexanol and carbon dioxide. In contrast, acid hydrolysis of 3-phenyl-l,2,3,4-oxatriazol-5-one (271, R = Ph) yields phenyl azide. Meso-ionic 3-cyclohexyl-l,2,3,4-oxatriazol-5-one shows two unusual reactions its photoirradiation in benzene gives cyclohexanone and heating with diphenylacetylene )delds l-cyclohexyl-4,5-diphenyl-1,2,3-triazole (276) rather than the expected 2-cyclohexyl-4,5-diphenyl-1,2,3-triazole. 

Allylic P-unsaturated,alcohols (geraniol, 3-phenyl-2-propenol) were efficiently oxidised to the aldehydes by fran.y-Ru(0)2(TMP)/(lutidine-iV-oxide)/CgHg [586]. As fran.y-Ru(0)2(TMP)/(Cl2pyN0)/CgHy24h it oxidised cyclohexanol to cyclohexanone [587]. 

Although there are measured enthalpies of formation of phenyl and cyclohexyl benzoylperoxycarbonate, there are none for the corresponding deoxygenated benzoylcarbonates that replace the —OO- moiety by —0-. The difference between the gas phase enthalpies of formation of the peroxy compounds, ca 258 13 klmol", is the hydrogenation enthalpy of the phenyl compound. This value is far in excess of the hydrogenation enthalpy of any other phenylated species from the enthalpies of formation of gaseous phenol and cyclohexanol, the difference is but 189.98 2.3 kJmol. ... 

Carroll, F.I., Brine, G.A., Boldt, K.G., Cone, E.J., Yousef-nejad, D., Vaupel, D.B., and Buchwald, W.F. Phencyclidine metabolism Resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(l-piperidinyl)- cyclohexanol. J. Med. Chem. 24 1047-1051, 1981. 

The discovery of 1 -aryl-1 -dimethylamino-cyclohexanes resulted from a surrey of compounds in which aromatic and basic features, both critical structural requirements of opioid analgesics, but usually separated by two or three carbon atoms, are linked to the same quaternary carbon. The synthesis of these compounds yielded a series of highly potent opioids (e.g. 1-Benzyl-4-(4-bromo-phenyl)-4-dimethylamino-cyclohexanol), however none of them are in clinical use (Lednicer et al., 1981). 

Therefore we used 4-androsten-3,17-dione 1 and 5a-androstan-3,17-dione 2 as model substrates to investigate the chemo- regio- and stereoselectivity of hydrogen transfer from different secondary alcohols, 2-propanol, 2-octanol, cyclohexanol, 1-phenyl-ethanol and diphenylmethanol in the presence of CU/AI2O3. In particular, hydrogenation of 1 allowed to determine the selectivity towards 5p isomers, whereas the percent of axial alcohol was derived from the hydrogenation of 2. These results can be compared with those obtained with the same catalyst in the presence of molecular hydrogen. 

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