Cyclodextrins polyethylenimine

Forrest ML, Gabrielson N, Pack DW (2005) Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene delivery. Biotechnol Bioeng 89(4) 416 123... 

Abstract Carbohydrates have been investigated and developed as delivery vehicles for shuttling nucleic acids into cells. In this review, we present the state of the art in carbohydrate-based polymeric vehicles for nucleic acid delivery, with the focus on the recent successes in preclinical models, both in vitro and in vivo. Polymeric scaffolds based on the natural polysaccharides chitosan, hyaluronan, pullulan, dextran, and schizophyllan each have unique properties and potential for modification, and these results are discussed with the focus on facile synthetic routes and favorable performance in biological systems. Many of these carbohydrates have been used to develop alternative types of biomaterials for nucleic acid delivery to typical polyplexes, and these novel materials are discussed. Also presented are polymeric vehicles that incorporate copolymerized carbohydrates into polymer backbones based on polyethylenimine and polylysine and their effect on transfection and biocompatibility. Unique scaffolds, such as clusters and polymers based on cyclodextrin (CD), are also discussed, with the focus on recent successes in vivo and in the clinic. These results are presented with the emphasis on the role of carbohydrate and charge on transfection. Use of carbohydrates as molecular recognition ligands for cell-type specific dehvery is also briefly... 

Pun S H, et al. (2004). Cyclodextrin-modified polyethylenimine polymers for gene delivery. Bioconjug. Chem. 15 831-840. 

A wide range of cyclodextrin-based supramolecular assemblies are now available,and in particular, the attachment of cationic polymers such as polyethylenimine has facilitated transport across cell membranes, permitting tar-getted delivery of both siRNA and DNA. ... 

Figure 25 Schematic of radiolabeled ( " Cu) supramolecular nanoparticle formed through the self-assembly of adamantane (Ad)-modified dendrimers (1), Ad-modified polyethylene glycol (Ad-PEG, 3), and cyclodextrin-modified polyethylenimine (CD-PEI, 2). (Reproduced from Ref. 82. Wiley-VCH, 2009.)...

I. Bohm, S.K. Kreth, and H. Ritter, Hyperbrcmched polyethylenimine bearing cyclodextrin moieties showing temperature and pH controlled dye release, Beilstein J. Org. Chem., 7, 1130-1134, 2011. 

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