Cushing-like symptoms

Adverse reactions of corticosteroids are frequent with the long-term immunosuppressive regimens which are often needed and include an increased risk of infections, Cushing-like symptoms, hypertension, hyperglycemia, osteoporosis, growth retardation in children and mental reactions such as dysphoria, psychosis and depression. 

Benign tumors in the pituitary or adrenal glands can lead to excess release of ACTH or cortisol into the blood, causing the symptoms of Cushing syndrome. Typically, excess levels of endogenous cortisol— not synthetic forms of cortisol—can cause hypertension, most likely because of its weak binding capacity with mineralocorticoid receptors (i.e., aldosterone receptors). 

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