Current Formulations

It is desirable to increase blast effect in the case of high capacity, light cased explosive weapons such as torpedoes, mines and high capacity aircraft bombs. It has been established beyond doubt that this is possible by the use of aluminized explosives which contain aluminum powder as an ingredient. 

A mixture of ammonium nitrate/TNT/aluminum powder/charcoal (65/15/17/3) called Ammonal had been used in World War I for mining, demolition and in bombs and grenades. However, in World War II, shortage of aluminum powder restricted its use for such HE formulations. The effect of addition of aluminum powder to high explosive fillings of bombs and shells had been found to be of advantage which is evident from the data given in Table 3.3. 

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Interlayer moisture is one of the important controls for PVB-to-glass adhesion of current formulations (although moisture-insensitive formulations are being developed). The moisture content equiUbrates with the relative humidity to which the interlayer is exposed and thus is variable. Prior to lamination, interlayer moisture content is measured by one of three methods. The most rapid is by air absorption using a spectrophotometric technique to determine a... 

Future efforts should be directed at optimizing current formulations to finally come up with an ideal oral contraceptive which would reduce the risk of breast, ovarian and endometrial cancer without any cardiovascular complications. 

This section has outlined the current formulations of quantum electrodynamics. Since the theory assumes its local form when expressed in terms of potentials, these formulations were in terms of the... 

Compare this with Equation (1.17) and note the difierence in rate constants. For the current formulation,... 

Two neuraminidase inhibitors (oseltamivir carboxylate and zanamivir) are approved for prevention and treatment of infections with both influenza A and B viruses as discussed in chapter by Itzstein and Thomson, this volume. Oseltamivir carboxylate (OC) has gained most use because it can be taken orally, whereas the current formulation of zanamivir has to be inhaled. In addition, the WHO reconunends oseltamivir for treatment of clinically confirmed cases of H5N1 and for post-exposme prophylaxis to control recent H5N1 avian influenza outbreaks. 

Extemporaneous production of pediatric dosage forms is commonly undertaken in hospitals. Without the sophisticated formulation capabilities of pharmaceutical manufacturers, alcohol-based vehicles have been recommended for extemporaneous preparation of liquid dosage forms [73]. There is a critical need to conduct research studies to assist the pharmacist in replacing current formulations with stable, alcohol-free preparations [74]. 

The ink for inkjet printers is essentially colored water, and the current formulation of ink is about 75% water, plus dye and glue (Kang 1991, Le 1998, Pond 1999). The ink should flow readily from ihe inkwell to the nozzle, and then to the paper, without dripping or clogging. The viscosity of current inkjet ink is from 2 to 8 cP. The droplets formed should be very uniform in size, and should be as small as possible to increase the resolution. When the droplet hits the paper, the droplet should penetrate the fibers without splatter, which would increase the diameter of the dot on the printed text or picture. The surface tension of current ink is around 45 to 50 dynes/cm, which is much lower than water at 70 dynes/cm. It is believed that if the surface tension is raised from 45 to 65 dynes/cm, the spread (or ratio of diameter of spot on paper/diameter of droplet) would decrease from 3.3 to 1.1. Much higher resolutions... 

A 20 run 2 fractional factorial design with four replicate center points was carried out to assess whether it was possible to optimize the current formulation for scale-up or if major reformation would be necessary. Table 3 lists the formulation variables that were evaluated. 

Lopinavir is currently formulated with ritonavir, which inhibits the CYP3A-mediated metabolism of lopinavir, thereby resulting in increased exposure to this drug. In addition to improved patient compliance due to reduced pill burden, lopinavir/ritonavir is generally well tolerated. 

Note that quantum phase is not a physical observable (at least in current formulations). The observable is n / or / 2. If, however, we have two (or more)... 

All the information about Dynamites manufd by the Apache Powder Co after WWI was obtd from the late Dr I.A. Grageroff. No info at our disposal about the current formulations of Apache Powder Co s explosives... 

AmB is a poorly water-soluble drug that is currently formulated with the bile salt deoxycholate (Fungizoni5). This formulation induces hemolysis and slowed release of AmB is shown to prevent this toxic side effect. In addition, Yu et al. investigated the effect of freeze-drying and reconstitution on the micelles. 

Most peptides and proteins are currently formulated as parenteral formulations because of their poor oral bioavailability. Nevertheless, oral delivery of peptides and proteins would be the preferred route of administration if bioavailability issues could be overcome, as it offers the advantages of convenient, pain-free administration. Although various factors such as permeability, chemical and metabolic stability and gastrointestinal transit time can affect the rate and extent of absorption of orally administered peptides and proteins, molecular size is generally considered the ultimate obstacle [36]. 

Immediately after these chemical treatments, all excess treatment solution must be washed off and the part well dried. The supplier of the primer should be consulted for current formulations to carry out chemical surface preparations. 

In its current formulation the ASEP/MD method introduces a dual representation of the solute molecule. At each cycle of the ASEP/MD calculation, the solute charge distribution is updated using quantum mechanics but during the molecular dynamics simulations the solute charge distribution is represented by a set of fixed point charges. The use of an inadequate set of charges in the solute description can introduce errors into the estimation of the solvent structure, and hence of the solute s properties... 

There are a range of drugs available. The regimen that suits Mrs GG best should be discussed there are currently formulations for daily, weekly and monthly administration with the likelihood of an annual dose preparation being possibly available. Weekly and monthly administration may improve compliance but... 

Because of these results, the current formulations (V, Chart I) for vincaleukoblastine have either a C-15 to C-4 linkage (site of hydroxyl is then a mystery) or a C-15 to C-3 linkage with the hydroxyl on C-3 or C-4 (stereochemistry not specified). These conclusions are acceptable, provided that the C-ethyl of the indole residue pre-exists in the dimer, but the only proof cited is the statement that the NMR is in agreement with structure V (13). The NMR argument should have excluded the possibility that an 18-carbomethoxydihydrocleavamine residue, rather than the 18-carbomethoxyibogamine skeleton, formed the indole moiety of the dimer. If V (Chart I) is to be accepted as true, then the most plausible linkage is... 

There have been numerous attempts to compare equations such as (XIV.10.23) with experiment and also to obtain other equations which involve explicitly the mechanism of flame propagation by diffusion of free radicals. It is doubtful, however, if the theory as currently formulated [for example, Eq. (XIV.10.23)] can be used for anything other than qualitative or semiquantitative prediction, particularly in view of the complex-... 

Here ao(T, V) and xo(7 > V) represent respectively the modified scalar electric polarizability and magnetic susceptibility. As before, we assume that these parameters do not depend on the intensity of the applied electromagnetic field such materials are said to be linear in their response to electromagnetic fields. Phenomena such as ferroelectricity and ferromagnetism are thus excluded from the current formulations. 

Liposomes are microscopic particles composed of a lipid bilayer membrane enclosing active drug in a central aqueous compartment (1). The aim of liposomal encapsulation of a drug is to alter its pharmacokinetics, thus improving efficacy and/or reducing toxicity (2). Current formulations of liposomal formulations of anthracyclines are as follows ... 

In case of partial change in the formulations during the development stage, clinical data with the current formulation can be used for the application data if bioequivalence between both formulations is confirmed. In cases of a slight change in oral formulation such cis a vehicle before Phase II trials, the dissolution test can be acceptable instead of the bioequivalence study. 

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