Curcumin arthritis

The principal use of the drug today is in treatment of acid, flatulent or atonic dyspepsic ulcers, and pain and inflammation due to rheumatoid arthritis. The antiinflammatory activity of Curcumas radix has been demonstrated in animal models, its effectiveness being similar to hydrocortisone acetate and indometh-acin. Curcumin and its derivatives are the active antiinflammatory constituents, and its activity appears to be mediated through the inhibition of the enzymes trypsin and hyaluronidase. Clinical studies (randomised, double-blind)... 

Ayurvedic medicine also uses herbal compounds both internally and externally for symptom relief. Topical curcumin may relieve the inflammation of rheumatoid arthritis. When taken in capsule form, it can reduce morning stiffness and boost endurance. A combination of Withania somnifera, Boswellia serrata, and Cucurma tonga also caused a significant drop in pain and disability for study participants with osteoarthritis. 

CURCUMIN SUPPRESSES SYMPTOMS ASSOCIATED WITH ARTHRITIS... 

Joe B, Lokesh BR (1997) Prophylactic and therapeutic effects of n-3 PUFA, capsaicin curcumin on adjuvant induced arthritis in rats. J Nutr Biochem 8 397-407... 

Curcuma extract, volatile oil, and its curcumin components have in vitro and in vivo antiinflammatory activity that may be due to inhibition of eicosanoid (leukotrienes/thrombox-anes) biosynthesis. A fraction of curcuma oil (b.p 80-110 °C) has been demonstrated to have anti-inflammatory and antiarthritic activities in rats. An essential oil-depleted extract is effective against experimental rheumatoid arthritis. Involved targets include NF-kB, che-mokine, COX-2, and others. Curcumin has also been reported to exhibit antiedemic effects in rats (martestdale). 

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