Curcumin antiproliferative effects

Several reports have described the anticancer activity of curcumin in a variety of cancer cell lines. In vitro studies have established the activity for curcumin against breast, gastric, hepatic, pancreatic, colorectal, urinary bladder, kidney, prostate, cervical, ovarian, uterine, lung, oral, thymic, and skin cancers. Besides these cancer types, curcumin has shown in vitro therapeutic efficacy against hematological cancers including leukemia, lymphoma, and multiple myeloma. One of our early studies established that the antiproliferative effect of curcumin in human breast cancer cell lines, including hormone-dependent, hormone-independent,... 

Howells LM, Mitra A, Manson MM. 2007. Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. Int J Cancer 121 175-183. 

Mehta, K., P. Pantazis, T. McQueen and B. Agarwal, 1997, Antiproliferative effect of curcumin against human breast tumor cell lines. Anticancer Drugs. 8,471-480. 

CURCUMIN EXHIBITS ANTIPROLIFERATIVE EFFECTS AGAINST CANCER CELLS... 

The effect of curcumin on apoptosis in multidmg-resistant cell lines has been reported. Piwocka et al. ° demonstrated that curcumin induced cell death in multidrag-resistant CEM(P-gp4) and LoVo(P-gp4) cells in a caspase-3-independent maimer. Mehta et al. also examined the antiproliferative effects of curcumin against multidrag-resistant (MDR) lines, which were found to be highly sensitive to curcumin. The growth-inhibitory effect of curcumin was time- and dose-dependent and was correlated with its inhibition of ornithine decarboxylase activity. Curcumin preferentially arrested cells in the G2/S phase of the cell cycle. 

Siwak DR, Shishodia S, Aggarwal BB, Kurzrock R. 2005. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 104 879-890. 

Chen and Huang examined the possible mechanisms underlying curcumin s antiproliferative and apoptotic effects using the rat VSMC cell line A7r5. Curcumin (1 to lOOpAT) inhibited serumstimulated pHJthymidine incorporation of both A7r5 cells and... 

---