Crystallation, avoidance strategy

Freeze-Avoidance Strategies Preventing Formation and Growth of Ice Crystals... 

How can particle size be controlled The answer is clear controlling primary nucleation and avoiding secondary nucleation and attrition can potentially enable chemists to achieve the same crystal size distribution with each batch. A later discussion outlines some of the inherent difficulties in these strategies and how best to overcome them. 

The general recommendation is to keep supersaturation levels in the low to medium range to prevent additional nucleation events. This strategy has an additional beneficial effect on purity owing to slow crystal growth, the purity of the final crystals is usually higher compared to that in the case of fast growth rates. Finally, the addition of seeds efficiently avoids the formation of amorphous material, which can later recrystallize in an uncontrollable fashion. 

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