Crystallization strategy

Weber, P. C. (1990). A protein crystallization strategy using automated grid searches on successively finer grids. 

Gilliland, G. L. A biological macromolecule crystallization database a basis for a crystallization strategy. Crystal Growth 90, 51-59 (1988). 

Overall, the FID assay and the H-G crystallization strategy, either singly or in combination (26), can assist in circumventing the usual slow steps associated with the analysis of DNA-ligand binding. Elimination of these historically slow steps would no doubt accelerate the discovery process and perhaps lead to the increased development and application of metal complexes towards biomedically-significant problems. 

Fig. 2 Edge-to-face stacking in organic semiconductor molecules (a) co-crystallization strategy applied to a thiophene and anthracene and (b) solid-state packing of p-PTE." °...

While a ditopic res-based template was successfully employed to synthesize the head-to-head photoproduct of p-PTE, we modified our co-crystallization strategy to generate the head-to-tail regioisomer. In addition to the O-H N heterosynthon involving a res and pyridine, carboxylic acids reliably form COOH N heterosynthons with pyridyl compounds. ... 

Our co-crystallization strategies were successful in the stereocontrolled syntheses of two cyclobutane-based regioisomers of p-PTE. The photostable packing arrangements involving P-PTE also demonstrated the propensity of thiophenes to adopt edge-to-face packings. ... 

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