Povidone crosslinked

Crosslinked povidone E1202 Kollidon CL Kollidon CL-M Polyplasdone XL Polyplasdone XL-10 polyvinylpolypyrroli-done PVPP l-vinyl-2-pyrrolidinone homopolymer. 

Cadexomer-H is an iodophor similar to povidone-iodine. It is a 2-hydroxymethylene crosslinked (1-4) a-D-glucan carboxymethyl ether containing iodine. The compound is used especially for its absorbent and antiseptic properties in the management of leg ulcers and pressure sores where it is applied in the form of microbeads containing 0.9% iodine. 

Povidone can become insoluble as a result of crosslinking, particularly at higher temperatures, if it is combined with strongly alkaline substances such as lithium carbonate or sodium hydroxide [141]. In extreme cases, this could result in an increase in viscosity in liquid dosage forms or delayed bioavailability in tablets and capsules [217]. 

Up to now, only isolated cases have become known, in which the stability of povidone has deteriorated in solid dosage forms. One of these is the combination with strongly alkaline substances, which can cause the polymer to crosslink, particularly at elevated temperatures [141]. As the example of lithium carbonate has shown many years ago, this can lead to a reduction in bioavailability [217]. 

With the methods given in Table 108, great care must be taken that no high-molecular povidone can be leached out of or peeled away from the plastics material in the body or in contact with body fluids. Povidone K 90 and povidone K 30 become insoluble hydrophilic substances after crosslinking. Alkaline treatment, e.g. with sodium hydroxide is an established and effective method. 

Coating of plastics with povidone followed by crosslinking by means of ... 

Povidone, crosslinked Sodium starch glycolate Starch... 

PoIy(N-vinylpyrrolidinone) (PNVP) has been used in medical applications for many years. Its history can be traced back to the Second World War where in its un-crosslinked form it was used as a blood plasma expander (I). This un-crosslinked PNVP when added to iodine forms a complex, in solution this complex is better known as Povidone-iodine or by its trade name Betadine , a surgical antiseptic. PNVP is also used as a binder in many pharmaceutical tablets as low molecular weight PNVP can be removed from the body by the kidneys. These polymers have also been investigated for use as wound dressings, drug... 

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