Cromoglycic acid

Chloro-oxazolo[4,5-/i]quinoline-2-carboxylic acid methyl ester was the most active compound in tests for inhibitors of antigen-induced release of histamine in vitro from rat peritoneal mast cells (IC50 of 0.3 p,M) and as inhibitors of IgE-mediated passive cutaneous anaphylaxis in the rat (ED50 (intraperitoneal) of 0.1 mg/kg in dose 0.5 mg/kg as an inhibitor of the test)—10 times and 60 times more potent, respectively, than the disodium salt of cromoglycic acid (85JMC1255). 

Alkylation of the dihydroxyacetophenone, 44, with epichloro-hydrin results in condensation of two molecules of the phenol with the latent glycerol (45). Reaction of the intermediate with ethyl oxalate affords the chromone ester, 46. Saponification leads to the bronchiodilator cromoglycic acid (47). The agent is usually administered by oral insufflation as its extremely insoluble disodium salt. 

Cromoglycic acid and nedocromil Development of radiolabelling method 37... 

A pulmonary anti-allergic for asthma therapy cromoglycic acid 45... 

Chromones have found uses in medicine for many years and it is possible to see in cromoglycic acid (XXX, Intal, FPL 670) the end-product of a long series... 

Two cautious, but hopeful, reviews [362,362a] concluded, from evidence then to hand that the currently available preparation of disodium cromoglycate with isoprenaline could benefit patients with allergic asthma, but both expressed the hope that results from cromoglycic acid without isoprenaline would soon clarify the position. 

In 1962, about 15 chromones were known to occur in plants but by 1975 this number had grown to 55 and has continued to grow. A few chromones have been known for many years to have pharmacological activity and the discovery in 1962 of cromoglycic acid (352)... 

Fig. 31 Esterification of dextran with cromoglycic acid using in situ activation with CDI...

Thin-layer Chromatography. Cromoglycic acid system TD—Rf 00 system TE—Rf 00 system TF—Rf 00. 

Barbituric Acid Carbazochrome Carbidopa Cromoglycic Acid Lysergic Acid Paramethadione Phthalylsulphacetamide Phthalylsulphathiazole Salicyluric Acid Succinylsulphathiazole Sulphasalazine Valproic Acid... 

Chan HK, Gonda I. Aerodynamic properties of elongated particles of cromoglycic acid. J Aerosol Sci 1989, 20, 157-168. 

Cromolyn. 5,5 -[ 2-Hydroxy-1,3-propanediyl)bis-(oxy)]bis[d-oxo-dH-l-bent.opyran-2-cn rboxylic acid] 5,5 -[i2-hydroxytrimethyiene)dioxy]bis<4-oxo-4H-t-benzopyran-2-carboxylic acid) 3,5 -(2-hydroxytrimethylenedioxy)bis(4-nxochromene.2-carboxylic acid) l,3-bis(2-carboxychro-mon -5 -yloxy) -2 - h yd roxy pro pan e 1,3 -di(2 -carboxy -4 -oxo -chromen-5-yloxy)propan-2-ol cromoglycic acid Dura-croman. mol wt 468.38. C 58,98%, H 3.44%, O... 

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