Emulsifying agents cremophor

Formulation studies are performed to develop a suitable vehicle to solubilize the drug for administration to patients, generally by intravenous injection or infusion in the case of cancer. The low solubility of many natural products in water poses considerable problems, but these can be overcome by use of co-solvents or emulsifying agents (surfactants) such as Cremophore EL (polyoxyethylated castor oil). 

To act as solubilizing, wetting, or emulsifying agents such as Cremophor EL, sodium desoxy-cholate, Polysorbate 20 or 80, PEG 40 castor oil, PEG 60 castor oil, sodium dodecyl sulfate, lecithin, or egg yolk phospholipid. 

Cremophors They are non-ionic solubilizer and emulsifying agent obtained by reacting hydrogenated castor oil with ethylene oxide. Two most commonly used cremophors are cremophor... 

Polyoxyl 35 castor oil is mainly used as an emulsifing and solubilizing agent, and is particularly suitable for the production of aqueous liquid preparations containing volatile oils, fat-soluble vitamins, and other hydrophobic substances. Cremophor EL emulsifies or solubilizes the fat-soluble vitamins A, D, E, and K in aqueous solutions for oral and topical administration. In 1 mL of a 25% v/v aqueous polyoxyl 35 castor oil (Cremophor EL) solution it is possible to incorporate approximately 10 mg of vitamin A palmitate approximately 10 mg of vitamin D approximately 120 mg of vitamin E acetate or approximately 120 mg of vitamin Kj. 

Uses Emulsifier, stabilizer, bodying agent, texturizer, ice crystal control agent, aerating agent in sorbet and sherbet Cremophor A 6 [BASF BASF AG Eigenmann Veronelli]... 

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