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COX-2 iNOS inhibition

Dl-R ligand ( 10),D2-R ligand (>10) (PA-R, O-R, PKC, TOPII) [AI, blocks COX-2 iNOS induction] Dl-R ligand (<10)(alA-R, a2A-R, 5HT1-R, O-R) [inhibits Epinephrine-induced adipocyte lipolysis]... [Pg.192]

ADH (COX, PGP TR, PK, RTK) [blocks COX-2 iNOS induction per IkB kinase inhibition antibacterial, AI, diuretic, hypotensive, nodulation stimulant]... [Pg.576]

PLA2 [inhibits LPS-induced COX-2, iNOS TNFa production]... [Pg.589]

The anti-inflammatory effects of nutraceuticals (curcumin, resveratrol, EGCG and other diaiylheptanoids) appear to be associated with their ability to inhibit NO, prosataglandins and cytokines. One of the most critical targets of these nutraceuticals involves NF-kB that regulates expression of a oIe variety of genes, such as COX-2, iNOS and proinflanunatory cytokines, responsible for inflammation (these targets are summarized in Figure 7). [Pg.58]

Hong CH, Sun KH, Jin O, Sun SK, Kyung AN, Sang KL. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002 83 153-159. [Pg.63]

Han M, Wen JK, Zheng B, Zhang DQ. Acetylbritannilatone suppresses NO and PGE2 synthesis in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 gene expression. Life Sci 2004 75 675-684. [Pg.66]

Andrographolide, thus, has different mechanisms of anti-inflammatory activity. It can inhibit the activation of NF-kB, suppress inducible nitric oxide synthase (iNOS) expression, inhibit COX-2 expression in human fibroblast cells and also prevent oxygen radical production by human. The compound is also able to modulate T-cell activation both in vitro as well as in vivo, it is evident that it could prevent initial T-cell priming by interfering with DC maturation and antigen presentation capacity. Therefore, andrographolide may have utility as a therapeutic agent for the treatment of autoimmune diseases, such as multiple sclerosis. " ... [Pg.343]

Activates PPAR-gamma which inhibits iNOS but not COX-2 expression in LPS-stimulated macrophages [65]... [Pg.256]

See other pages where COX-2 iNOS inhibition is mentioned: [Pg.545]    [Pg.603]    [Pg.610]    [Pg.545]    [Pg.93]    [Pg.177]    [Pg.861]    [Pg.444]    [Pg.127]    [Pg.210]    [Pg.2207]    [Pg.2679]    [Pg.33]    [Pg.887]    [Pg.888]    [Pg.53]    [Pg.63]    [Pg.190]    [Pg.71]    [Pg.342]    [Pg.397]    [Pg.423]    [Pg.19]    [Pg.40]    [Pg.50]    [Pg.207]    [Pg.143]    [Pg.123]    [Pg.79]    [Pg.92]    [Pg.98]    [Pg.687]    [Pg.354]    [Pg.15]   
See also in sourсe #XX -- [ Pg.79 ]

See also in sourсe #XX -- [ Pg.79 ]



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Inhibition of iNOS and COX-2 gene

Inhibition of iNOS and COX-2 gene expression

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