Covalent ligands

Axle and collar molecular structure, 27 60-61 Axokine, 3 97 Azaboranes, 4 170, 204 Azacarbocyanine dyes, 9 257 Aza[18]crown-6, 24 41 Aza[18]crown-6 appended a-helical barrels / rods, 24 58 Azacrown ethers, 24 44 Azacrowns, 24 41 Azacryptands, 24 42 Azadirachtin, 24 474 Azafullerenes, 22 231, 232, 243 Azahomofullerenes, 22 243 Azaindene compounds, 29 197 Azalactone method (for Emphaze supports), for covalent ligand immobilization, 6 396t Azamethiphos (salmosan)... 

Carbocations, 12 161—162, 163 from alkanes, 12 187 Carbocation salts, stable, 14 269 Carbochlorination, zircon, 13 82 Carbocyclic azo dyes, 9 245, 251 Carbodiimide (CDI) method, for covalent ligand immobilization, 6 396t Carbohydrate chemistry, microwaves in, 16 547-548... 

Cyanogen bromide (CNBr) method, for covalent ligand immobilization, 6 396t Cyanogen chloride, 3 172 Cyanoguanidine, 3 164 Cyanohydrins, 27 229... 

Divinyl sulfide, 25 630 Divinylsulfone method, for covalent ligand immobilization, 6 3961 Division of Chemical Nomenclature and Structure Representation (IUPAC),... 

Hydrazide method, for covalent ligand immobilization, 6 396t Hydrazine, 70 727 73 562-607. See also Anhydrous hydrazine analytical methods for, 73 588-589 aqueous grades of, 73 585 chemical properties of, 73 566-576 as a corrosion inhibitor, 73 595 economic aspects of, 73 584-585 electrode potentials of, 73 566t explosive limits of, 73 566 handling and storage of, 73 586-588 as a hazardous material, 73 585... 

Scheelite, 25 349-350 Scheelite sorting, 16 626 Scheibel column, 10 777-778 Scheibler filter, 11 364 Schiff base(s), 21 203, 204, 25 100-101 chelating agents, 5 712t reaction with amino acids, 2 567 reaction with aniline, 2 786 thermochromic materials, 6 622-623 Schiff base chemistry, 24 42 Schiff base (reductive amination) method, for covalent ligand immobilization, 6 396t... 

Ultraviolet irradiation (for cellulose), for covalent ligand immobilization,... 

Chemical interactions of ligands with these receptors may involve the formation of many types of bonds, including ionic, hydrogen, van der Waals , and covalent Ligand-receptor interactions are often stereospecific (i.e., one stereoisomer is usually more potent than the other)... 

The route of taxanes was finally unveiled with the use of a covalent ligand of the taxane binding site [21], Cyclostreptin, abacterial natural product [46,47] with weak, but irreversible tubulin assembly activity and strong apparent binding affinity for the paclit-axel site, covalently labels both a residue placed in the lumenal site of paclitaxel Asn228 and a residue previously proposed to be in the external binding site Thr220 (Fig. 3a). 

Schwartz, B. L., Gale, D. C., Smith, R. D., Chilkoti, A., and Stayton, P. S. (1995). Investigation of non-covalent ligand binding to the intact strepavidin tetramer by electrospray ionization mass spectrometry. J. Mass Spectrom. 30, 1095-1102. 

Huang H, Melacini G. High-resolution protein hydration NMR experiments probing how protein surfaces interact with water and other non-covalent ligands. Analyt. Chim. Acta 2006 564 1-9. 

Let us examine first the principal sites of tagging ruthenium complexes (Scheme 1.41) they include covalent ligands A [phosphines, N-heterocyclic carbenes (NHCs) or pyridine], anionic ligands B, or the carbene ligand C (either in the aromatic moiety or at the alkoxy ligand). 

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