Cotton pellet granuloma

Anti-implantation effect. Ethanol (50%) extract of the dried leaf, administered intragastrically to hamsters at a dose of 100 mg/kg, was active ° 5 Anti-inflammatory effect. EAM, administrated orally to rats, produced anti-inflammatory activity in the cotton pellet granuloma assay and in the carrageenin-induced pleurisy test. The effect was also produced in the peritoneal capillary permeability test in mice °° . 

The anti-inflammatory and antihypoproliferative activities of this compound were compared to those of other compounds in several animal models. The compound was 1300-fold more potent than hydrocortisone, and 11-fold more potent than clobetasol propionate, respectively, in suppressing the erythemal responses in a guinea pig model of UV-induced inflammation, and it was 10-fold more potent than clobetasol in the cotton pellet granuloma assay in rats. 

Anti-inflammatory activity in the cotton pellet granuloma test (pg/pellet). 

Indomethacin is a potent anti-inflammatory and anti-pyretic compound. Given orally, it inhibits the formation of the cotton-pellet granuloma in the rat, being about 85 times more potent than phenylbutazone, and equally active in both intact and adrenalectomized rats. It inhibits oedema of the rat-foot, produced by either carrageenan or mustard, but does not inhibit that produced by egg-white, formalin, yeast or 5-hydroxytryptamine. As an antipyretic, it is 10-20 times more powerful than phenylbutazone. Indomethacin is well absorbed in all species, but there is considerable variation in its distribution and metabolism. Man tolerates the drug better than do other species, and is less liable to the gastro-intestinal irritation encountered in experimental animals . ... 

Sodium aurothiomalate in a dose of 4 mg weekly reduces permeability of the rabbit synovial membrane . The same compound, given intramuscularly in a daily dose equivalent to 0-75 mg of elemental gold, reduced the cotton-pellet granuloma in rats, an effect thought to be due to an increased turnover of adrenocorticosteroids . 

Fig. 205. Cotton pellet granuloma 7 days after subcutaneous implantation in a 120 g male Sprague-Dawley rat (No. 3 February 4, 1969). Fixed by immersion in Bonin s fluid. Paraplast 4 pm. Haematoxylin and eosin. Objective Leitz PI 40/0.65. Leitz-Orthomat. Agfachrome 50 L professional...

Another study was made on the anti-inflammatory effect in rodents of the EO of the Euphor-biaceae Croton cajucara Benth. (Sacaca, Euphorbiaceae) by Bighetti et al. (1999). At a dose of 100 mg/kg the EO exerted an anti-inflammatory effect in animal models of acute (canageenin-induced paw edema in mice) and chronic (cotton pellet granuloma) inflanunation. Compared with the negative control a dose-dependent reduction of carrageenin-induced edema was achieved. This EO also reduced chronic inflammation by 38%, whereas diclofenac only achieved an inhibition of 36%. The migration of neutrophils into the peritoneal cavity could not be inhibited by the EO. The anti-inflammatory effect seemed to be related to the inhibition of COX. 

Rats Anti-inflammatory activity of piperine in experimental models carrageenan- induced rat paw edema, cotton pellet granuloma, croton oil-induced granuloma pouch [79]... 

Ethanolic extract has exhibited anti-inflammatory (vs. carrageenan-induced paw edema and cotton pellet granuloma in rats) and analgesic effects it also inhibited growth of Bacillus subtilis ... 

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