Croton cajucara

Another study was made on the anti-inflammatory effect in rodents of the EO of the Euphor-biaceae Croton cajucara Benth. (Sacaca, Euphorbiaceae) by Bighetti et al. (1999). At a dose of 100 mg/kg the EO exerted an anti-inflammatory effect in animal models of acute (canageenin-induced paw edema in mice) and chronic (cotton pellet granuloma) inflanunation. Compared with the negative control a dose-dependent reduction of carrageenin-induced edema was achieved. This EO also reduced chronic inflammation by 38%, whereas diclofenac only achieved an inhibition of 36%. The migration of neutrophils into the peritoneal cavity could not be inhibited by the EO. The anti-inflammatory effect seemed to be related to the inhibition of COX. 

Lapa, A. R. Agner, I. M. S. Colus, J. Echevarria-Lima, N. F. Grynberg, A. Esteves-Souza, K. Pissinate and A. Echevarria, Pharmacological and Biochemical Profiling of Lead Compounds from Traditional Remedies The Case of Croton Cajucara , in Advances in Phytomedicine, eds. M. Khan and... 

Further examples of application of /hh couplings in structural studies of natural products include frans-dehydrocrotonin, a bioactive 19-nor-diterpenoid clerodane type, isolated by Soares et from Croton cajucara... 

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