Corticosteroids Diuretics, thiazide

Established interactions. The CSM in the UK advises that, as potentially serious hypokalaemia may result from beta2 agonist therapy, particular caution is required in severe asthma, as this effect may be potentiated by theophylline and its derivatives, corticosteroids, diuretics, and by hypoxia. Hypokalaemia with concurrent use of thiazide and loop diuretics may be reduced or even abolished by the addition of spironolactone or high-dose triamterene. Plasma potassium levels should therefore be monitored in patients with severe asthma. Hypokalaemia may result in cardiac arrhythmias in patients with ischaemic heart disease and may also affect the response of patients to drugs such as the digitalis glycosides and an-tiarrhythmics. 

CEC-MS is used as an analytical tool for pharmaceutical analysis. The CEC-ESI-MS analysis and quantification of a potential drug candidate from 13 structurally related compounds in extracted plasma were reported by Paterson et al. [26]. The CEC colunm was packed with an experimental mixed mode stationary phase containing both Ci8 and sulfonic acid ligands. These phases promote stable electroosmotic flow across a wide range of pH values and allow a greater choice of buffer pH values. The mobile phase was acetonitrile/25 mM ammonium acetate (75 25) at pH 3.5 adjusted with acetic acid. Taylor et al. reported a CEC-ESI-MS analysis of mixtures of benzodiazepines, corticosteroids and thiazide diuretic drugs [27]. 

Thiazides and related diuretics are used in the treatment of hypertension, edema caused by CHF, hepatic cirrhosis, corticosteroid and estrogen therapy, and renal dysfunction. 

Drugs that may affect repaglinide include CYP 450 inhibitors (eg, clarithromycin, erythromycin, ketoconazole, miconazole), CYP 450 inducers (eg, barbiturates, carbamazepine, rifampin), beta blockers, calcium channel blockers, chloramphenicol, corticosteroids, coumarins, estrogens, gemfibrozil, isoniazid, itraconazole, levonorgestrel and ethinyl estradiol, MAOIs, nicotinic acid, NSAIDs, oral contraceptives, phenothiazines, phenytoin, probenecid, salicylates, simvastatin, sulfonamides, sympathomimetics, thiazides and other diuretics, and thyroid products. 

Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. 

Corticosteroids, corticotrophin, diazo-xide, diuretics (bumetanide, furosemide, thiazides), orai contraceptives Antagonism. 

Thiazides and other diuretics Corticosteroids Phenothiazines Thyroid products Estrogens Oral contraceptives Phenytoin Nicotinic acid Sympathomimetics Calcium channel blockers Isoniazid Miconazole... 

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