Copper defidency

Sutton AM, Harvie A, Cockburn F, Farquharson J, Logan RW (1985) Copper defidency in preterm infants of very low birthweight. Four cases and a reference range for plasma copper. Arch Dis Childh 60 644-651. 

In cattle, a relationship exists between molybdenum, capper, and sulfur. Excess motybdenum wil cause copper defidency. However, when the site content of the diet is increased, the symptoms el loxiciiY are avoided inasmuch as the excretion of motyb-denum is increased... 

Copper deficiencies are most common in soils that are peaty, add-leached, coarse-textured, or calcareous. Soils with less than 8 ppm total Cu may be defident for crops. 

FIGURE 5S Yeast-based screen for inhibitors of human PDE IV. A PDE-defident yeast (PMY) will not utilize acetate as a sole carbon source and is sensitive to heat shock (55°C). Complementation with a human type IV PDE (PMY + PDE) expressed from a copper-dependent (CUPl) promoter reverses the mutant phenotype. Addition of type IV PDE inhibitor (roUpram) to the complemented yeast restores the mutant phenotype (PMY + PDE -I- rolipram). 

Finally, it should be noted that there is a series of copper-containing complex compounds with superstructures based on anion-defident perovskite type. These have been the subject of intense research in recent years, because of their remarkable high-temperature superconducting properties, and many appropriate reviews have been produced. 

Extrinsic labeling has been used in several studies to assess apparent copper absorption inhumans. This includes studies to evaluate apparent copper absorption from plant- and animal-based diets [263, 264], and also the effect of ascorbic acid [265], age [146, 266, 267], copper intake [267-271], zinc intake [146], and iron supplementation [272] on copper absorption. By measuring urinary excretion of the tracer, copper retention has also been assessed from vitamin B6-defident diets [271], in pregnant women [263], in young men consuming a low copper diet [268], and for high copper intakes [270]. 

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