Sodium-copper-chlorophyllin

Potassium sodium copper chlorophyllin (chiorophyllin—copper complex)—A green-black powder obtained from chlorophyll by replacing the methyl and phytyl ester groups with alkaH and replacing the magnesium with copper. The source of the chlorophyll is dehydrated alfalfa. 

Hydrolysis of chlorophyll using sodium hydroxide produces the moderately water-soluble sodium salts of chlorophyllin, phytol and methanol (145). The magnesium ia chlorophyllin may be replaced by copper. The sodium copper chlorophyllin salt is heat stable, and is ideal for coloring foods where heat is iavolved, such as ia canning (146). 

Chemical analysis revealed that commercial food grade copper chlorophyllin is not a single, pure compound, but is a complex mixture of structurally distinct porphyrins, chlorin, and non-chlorin compounds with variable numbers of mono-, di-, and tri- carboxylic acid that may be present as either sodium or potassium salts. Although the composition of different chlorophyllin mixtures may vary, two compounds are commonly found in commercial chlorophyllin mixtures trisodium Cu (II) chlorin Cg and disodium Cu (II) chlorin which differ in the number of... 

Fermzzi, M.G. and Schwartz, S.J., Thermal degradation of commercial grade sodium copper chlorophyllin, J. Agric. Food Chem., 53, 7098, 2005. 

U.S. Eood and Drug Administration, Listing of color additives exempt from certification sodium copper chlorophyllin, 21CER Part 73, 67 Fed. Reg. 35429, May 20, 2002. 

Sodium copper chlorophyllin, approved by the FDA as a color additive in citrus-based dry beverage mixes, should have a ratio of absorbance (SoretQ band) not less than 3.4 and not more than 3.9. In Europe, purity criteria of the food additives E141[i] and E141[ii], which are copper complexes of chlorophyll and chlorophyllin, respectively, are set out in the EC color specifications that include identification and spectrophotometric assay tests. ... 

Purity levels of commercial preparations have also been estimated based on their Cu contents and compared with the theoretical values expected for fuUy coppered chlorophyllin based on the two major compounds Cu(ll) chlorin e4 (disodium salt) and Cu(ll) chlorin e6 (trisodium salt). The expected theoretical content of copper in a pure Cu chlorophyllin complex is 9.2%, which has never been found in commercial preparations. The sodium copper chlorophyllin from Sigma-Aldrich (St. Louis, MO) has a 4.5% copper content, specified by the manufacturer with respect... 

Spray 521,700 units papain, 10% urea, 0.5% chlorophyllin copper complex sodium per g (Rx)... 

Chlorophyll. Chemically pure chlorophyll is difficult to prepare, since it occurs mixed with other colored substances such as carotenoids. Commercially it is solvent extracted from the dried leaves of various plants such as broccoli or spinach. Chlorophyll is water-iosoluble. It has none of the characteristics of a dye in that it has no aflinity for the usual libers such as cotton or wool. Chlorophyll is properly classified as a pigment tCI Natural Green 3 Cl 75810), As such. It finds use lor coloring soaps, waxes, inks. fats, or nils. Chlorophyll is an ester composed of an acidic pint, chlorophyllin, esterilied by an aliphatic alcohol known as phylol. Hydrolysis of chlorophyll using sodium hydroxide produces the moderately water-soluble sodium salts of chlorophyllin. phytol. and methanol. The magnesium in chlorophyllin may be replaced by copper. The sodium copper chlorophyllin salt is heat-stable, and is ideal for coloring foods where heat is involved, such as in canning. 

Sato, M., Fujimoto, I., Sakai, T., Aimoto,T., Kimura, R., and Murata, T. 1986. Effect of sodium copper chlorophyllin on lipid peroxidation. IX. On the antioxidative components in commercial preparations of sodium copper chlorophyllin. Chem. Pharm. Bull. 34 2428-2434. 

Potassium or sodium copper chlorophyllin Potassium or sodium chlorophyllin Color of porphyrin ADI 0-15... 

The ointment is an enzymatic debriding-healing ointment that contains standardized papain USP (not less than 521,700 USP units per gram of ointment), urea USP 10%, and chlorophyllin copper complex sodium 0.5% in a hydrophilic base composed of purified water USP, propylene glycol USP, white petrolatum USP, stearyl alcohol NF, polyoxyl 40 stearate NF, sorbitan monostearate NF, boric acid NF, chlorobutanol (anhydrous) NF (as a pre-... 

Poly(A -isopropylaciylamide-co-butyl acrylate-co-chlorophyllin sodium copper salt) dextran and water dextran and water poly[2-(A, iV-dimeihylamino)ethylmethaciylate-co-aciylic acid-co-butyl methacrylate] and water 2007KON 2009SHA 2009NIN... 

Poly[A/-isopropylaciylainide-co-iV-(3-aiiiinopropyl)methaciylaiiiide hydrochloride-fe-iV-isopiopylaciylaniide] Poly(A -isopropylaciylainide-co-beiizo-15-crown-5-aciylaiiiide) Poly[A -isopropylacrylamide-co-(iV-(R,S)-5ec-butylaciylaniide)] Poly[A -isopropylaciylamide-co-(A -(S)-,sec-butylaciylainide)] Poly(A -isopropylacrylamide-co-butyl acrylate) Poly(A -isopropylaciylamide-co-butyl acrylate-co-chlorophyllin sodium copper salt)... 

Synonyms CCC Chlorophyllin, copper sodium complex Cl 75815 Copper sodium chlorophyllin Potassium sodium copper chlorophyllin... 

Boith China http //www.boith.com, Charles Bowman http //www.chariesbowman.com, Generi chem http //www.generichem. com, Morre-Tec Ind. http //www.morretec.com, P.L. Thomas http //www.pithomas.com R.W. Greeff http //www.pechiney-chemicais.com, RIA Int l. http //www.riausa.com. Seltzer http //www.seitzerchemicais.com. Sigma Synasia Fine Chem. http //www.synasia.com Universal Preserv-A-Chem http //www.upichem.com, Vopak USA http //WWW. vopakusa. com Trade Name Synonyms Potassium Sodium Copper Chlorophyllin 033280 t[Chr. Hansen Inc] Uniphyllin SC [Universal Preserv-A-Chem http //www.upichem.com]... 

Sodium copper chlorophyllin. See Chlorophyllin-copper complex... 

Potassium Sodium Copper Chlorophyllin 033280 Uniphyllin SC 11006-75-0 Saponins... 

Poly[2-(A/ A/-dimethylamino)ethyl methacrylate-co-acrylic acid-cobutyl methacrylate] poly(A -isopropylacrylamide-co-butylacrylate-co-chlorophyllin sodium copper salt) and water 2009N1N... 

Poly(A -isopropylaciylainide-co-butyl acrylate-co-chlorophyllin sodium copper salt) dextran and water 2007KON... 

Later, the identification of Cu-chlorin and Cu-chlorin ethyl ester in serum of human subjects ingesting sodium-copper-chlorophyllin provided evidence that such compounds can be absorbed by humans [62], In fact, Ferruzzi et al. [63] demonstrated the stability of Cu(II)-chlorine 4 during in vitro digestion and the effective uptake by Caco-2 enterocyte-like cells, supporting the likelihood that a portion of sodium-copper-chlorophyllin component or its metabolites are absorbed from the human intestine. 

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