Cooperativity regulation

Janda E, Lehmann K, Killiseh I et al. Ras and TGF[beta] cooperatively regulate epithelial eell plasticity and metastasis disseetion ofRas signaling pathways. J Cell Biol 2002 156 299-313. 

The enzymatic activities are also subjected to allosteric/cooperative regulations (Monad et al., 1965 Perutz, 1990 Ricard and Cornish-Bowden, 1987). A regulatory molecule (effector) binds to the regulatory site (allosteric site) distinct from the catalytic site to affect one or more kinetic parameters of an enzymatic reaction. 

Ashburner, B.P., and Lopes, J.M., 1995a, Autoregulated expression of the yeast INOl and I NO 4 helix-loop-helix activator genes effects cooperative regulation on their target genes. Mol. Cell. Biol. 15 1709-1715. 

Look at cooperativity/regulation curves for enzymes/binding proteins. Get two families of regulators ... 

Inaishi, Y., Kashihara, Y., Sakaguchi, M., Nawa, H., and Kuno, M., Cooperative regulation of calcitonin gene-related peptide levels in rat sensory neurons via their central and peripheral processes, J. Neurosci., 12, 518, 1992. 

O Toole, C.M.B. and Florman, H.M. Cooperative regulation of intracellular Ca stores in sperm by pH and IP3 during the zona pellucida-induced acrosome reaction. (Unpublished.)... 

PXR and CAR cross talk at the DR4(I) element of the -7.8-kb enhancer of MDR1. Competition of both nuclear receptors for binding to DR4(I) has to be anticipated, as they bind to this element with comparable relative affinities [149]. However, cooperative regulation of MDR1 expression by PXR and CAR is also conceivable, as CAR exhibits specific binding to the extended 5 half site of DR4(II). 

Sasaki, Y., Takahashi, Y., Nakayama, K., and Kamataki, T. (1999) Cooperative regulation of CYP2C12 gene expression by STAT5 and liver-specific factors in female rats. J. Biol. Chem. 274, 37117-37124. 

Bilder, D., M. Li, and N. Perrimon. 2000. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289 113-116. 

A number of other cytokines have been shown to regulate mRNA ° synthesis, and a summary of the effects reported for cultured cells is presented in Table 2. Cooperative regulation of NGF synthesis and secretion by cytokines has been observed in cultured astrocytes and fibroblasts (Yoshida and Gage, 1992). 

Marston SB, Redwood CS (1993) The essential role of tropomyosin in cooperative regulation of smooth muscle thin filament activity by caldesmon. J Biol Chem 268 1231712320... 

Stretching Delaney Till It Breaks", Richard M. Cooper, Regulation, November/December 1985, pg. 11-17,41... 

Hu, Z., Yu, D., Almeida-Suhett, C., et al., 2012. Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury. 

Claybrook, Retreat From Safety, 72-75 (cooperative regulator quote) Curran, Dead Laws, 154-57,162-67 McGarity Shapiro, Workers at Risk, 61—74, 80-83,9 > H9 5°i Michael Wines, Auchter s Record at OSHA Leaves Labor Outraged, Business Satisfied, 15 Nat. J. 15 (1983). 

---