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Convulsions, definition

According to Eddy, as quoted by Small, the analgesic action of neopine, n omorphine, 6-acetylneomorphine or 3 6-diacetylneomorphine (p. 218) is definitely less than that of morphine and its corresponding analogues. The first two are about half as toxic as codeine and morphine respectively, and the second pair are more toxic than their morphine analogues. None of the four shows the Straub reaction and the convulsant action is less marked. [Pg.265]

Definitive treatment of preeclampsia is delivery, and this is indicated if pending or frank eclampsia (preeclampsia and convulsions) is present. Otherwise, management consists of restricting activity, bedrest, and close monitoring. Salt restriction or other measures that contract blood volume should be avoided. Antihypertensives are used prior to induction of labor if the DBP is >105-110 mm Hg, with a target DBP of 95-105 mm Hg. IV hydralazine is most commonly used IV labetalol is also effective. [Pg.139]

Few data were available that met the definitions of AEGL end points. One inhalation study with 20 human subjects described headaches and slight loss of balance at exposure concentrations of 0.1 to 1.5 ppm for exposure durations of up to 8 h (Stewart et al. 1974). Acute exposure of monkeys for 6 h at concentrations ranging between 70 and 100 ppm resulted in severe signs of toxicity including convulsions but no deaths (Jones et al. 1972). In the same study, exposure of rats at a higher concentration, 189 ppm for 4 h, resulted in no toxic signs. Examination of the relationship between exposure duration and concentration for both mild and severe headaches in humans over periods of 1 to 8 h determined that the relationship is C xt=k. [Pg.89]

Febrile convulsions generally occur between six months and 3 years of age. A family history of epilepsy is not definitely associated with an increased risk of febrile convulsions, but if they happen they are more likely to recur. The younger the age group the higher the risk of recurrence (especially <1 year). By the age of 8 years only 3% of children who have had a febrile convulsion will have developed epilepsy and the two events seem unrelated. [Pg.401]

The safety and efficacy of oral cyclodextrin itraconazole (5 mg/kg/day) as antifungal prophylaxis has been assessed in an open trial in 103 neutropenic children (median age 5 years range 0-15 years) (53). Prophylaxis was started at least 7 days before the onset of neutropenia and continued until neutrophil recovery. Of the 103 patients, only 47 completed the course of prophylaxis 27 withdrew because of poor compliance, 19 because of adverse events, and 10 for other reasons. Serious adverse events (other than death) occurred in 21 patients, including convulsions (n = 7), suspected drug interactions (n = 6), abdominal pain (n — 4), and constipation n — 4). The most common adverse events considered definitely or possibly related to itraconazole were vomiting (n = 12), abnormal liver function (n — 5), and abdominal pain (n = 3). Tolerabihty of the study medication at end-point was rated as good (55%), moderate (11%), poor (17%), or unacceptable (17%). There were no unexpected problems of safety or tolerability. [Pg.1937]

Beck studied the acute toxicity, upon intraperitoneal injection, to mice of each compound. The anhydride was definitely less toxic. Erythritol in doses of 0.8 to 0.9 g. per 100 g. of mouse caused definite hypersensitivity, later convulsions, followed by death in two to three hours. Doses of 1.8 g. per 100 g. of mouse of erythritan produced convulsions followed by a lingering depression, ending usually in the death of the animal. [Pg.179]

As noted under the heading of general anesthetics, there are other allosteric sites that recognize re.spectively. neuro-.stcroids. barbiturates, inhalation anesthetics, alcohols and the phenol Diprivan (.separate sites). The convuLsants picro-toxin and pcntylenetetrazole have definite binding sites on GABA receptors. [Pg.489]

Repeated inhalation of high concentrations of aluminum may result in aluminosis or lung fibrosis. Accumulation of aluminum particles in the kidney may occur especially among dialysis patients, as the dialyzing solution may contain high concentrations of this metal (Hodgson et al. 1988). This may result in impaired memory, dementia, ataxia, and convulsions. Accumulation in brain has been suggested as a factor in Alzheimer disease. The evidence is not definitive, however. [Pg.647]


See other pages where Convulsions, definition is mentioned: [Pg.256]    [Pg.212]    [Pg.337]    [Pg.147]    [Pg.152]    [Pg.537]    [Pg.542]    [Pg.550]    [Pg.561]    [Pg.568]    [Pg.574]    [Pg.579]    [Pg.581]    [Pg.582]    [Pg.585]    [Pg.322]    [Pg.119]    [Pg.167]    [Pg.93]    [Pg.18]    [Pg.28]    [Pg.231]    [Pg.1169]    [Pg.287]    [Pg.263]    [Pg.294]    [Pg.3553]    [Pg.34]    [Pg.129]    [Pg.202]    [Pg.1049]    [Pg.78]    [Pg.262]    [Pg.130]    [Pg.120]    [Pg.147]    [Pg.152]   
See also in sourсe #XX -- [ Pg.577 ]

See also in sourсe #XX -- [ Pg.577 ]




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