Controlled pack sizes

Products categorised as GSL medicines have strict controls concerning their strength, use, pharmaceutical form and route of administration. The maximum dose or maximum daily dose will also be controlled for medicines for internal use. Another control that may be enforced is pack size, with a limit to the size of pack allowed as a GSL medicine. Examples of GSL medicines that have controlled pack sizes include ... 

New templated polymer support materials have been developed for use as re versed-phase packing materials. Pore size and particle size have not usually been precisely controlled by conventional suspension polymerization. A templated polymerization is used to obtain controllable pore size and particle-size distribution. In this technique, hydrophilic monomers and divinylbenzene are formulated and filled into pores in templated silica material, at room temperature. After polymerization, the templated silica material is removed by base hydrolysis. The surface of the polymer may be modified in various ways to obtain the desired functionality. The particles are useful in chromatography, adsorption, and ion exchange and as polymeric supports of catalysts (39,40). 

FIG. 14-119 Aerodynamic cut diameter for a typical packed-bed entrainment separator as a function of packing size, bed depth, and three gas velocities curve 1-1.5 m/s, curve 2-3.0 m/s, and curve 3-4.5 m/s. To convert meters to feet, multiply by 3.281 to convert centimeters to inches, multiply by 0.394. [Calvert, ]. Air Pollut. Control Assoc., 24, 929 (1974).]... 

SEC (Size Exclusion Chromatography)—A separation mode employing control pore size packing to achieve resolution of molecules based on size and shape. (See GPC.)... 

CEC packed SEC Controlled pore size silica Size, charge and exclusion... 

In the European Union, the requirements should be formally authorized in the packaging instructions for each product containing pack size and type. They are normally included in process controls with instructions for sampling and acceptance limits [42],... 

Using this method to form a nanoparticle coated surface allowed us to better control the size of the nanostructures, but still generated a random distribution of nanoparticles. The density of silver nanostructures could be controlled by both the amount of time the substrate was immersed in the colloidal solution and the concentration of the colloidal solution. Because the size of the metal structures is directly determined by the colloids, sparse to densely packed colloid coated surfaces that maintain a unique metal nanostructure size could be produced by simply varying the incubation time in the colloid solution. 

The Act makes provision for the legal status of all medicines as either prescription only (POM), general sale (GSL), or by default pharmacy (P) a medicine is Pharmacy status unless listed in the POM or GSL Orders. Some medicines are exempted from POM status (making them P status) if their active substance is within specified limits for strength, dose, pack size, use, route of administration, or dose form. Some medicines may be disallowed from GSL status (making them P status) because their active substance is outside the specified limits for strength, dose, pack size, use, route of administration, or dose form. Pack size of certain GSL medicines is controlled by the Sale and Supply Regulations. 

The concept of RAM combines a hydrophilic external surface and a hydrophobic internal surface in silica particles with controlled pore sizes (Fig. 9). Large biopolymers, such as proteins, are prohibited from entering the pores of the packing and are not well retained by the column. Therapeutic drugs and other small molecules permeate the pores of the column packing material, where they partition and are retained. This approach is, in principle, a combination of size exclusion and partition chromatography. In practice, to obtain a reasonable... 

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