Controlled monitored dosage systems

Controlled dosage systems (also called monitored dosage systems)... 

Most controlled release dosage forms administer dmg according to thek design, whether conceptually simple, eg, a fixed release rate for a fixed amount of time, or complex, eg, several different rates for different amounts of time. Alternatively, closed-loop systems contain a sensor to monitor dmg concentration or to administer dmg according to a biological need (11). 

Dissolution rate tests for tablets, capsules, suspensions, suppositories, or other dosage forms. Controlled-release dosage forms or drug delivery systems also should be monitored by appropriate testing methodology. 

Operation When operated correctly, thickeners require a minimum of attention and, if the feed characteristics do not change radically, can be expected to maintain design performance consistently. In this regard, it is usually desirable to monitor feed and underflow rates and sonds concentrations, flocculant dosage rate, and pulp interface level, preferably with dependable instrumentation systems. Process variations are then easily handled by changing the principal operating controls—underflow rate and floccirlant dose—to maintain stability. 

The water is treated with UV radiation for primary disinfection, then chlorinated for secondary disinfection. An applied chlorine dosage of only about 1 mg/L is necessary. The entire water treatment system is housed in a 2.97 m (32 fU) building. The UV disinfection system consists of six irradiation chambers, two control cabinets with alarms, chart recorders, relays, hour-run meters, lamp and power on-lights, six thermostats, electrical door interlocks, mimic diagrams, and six UV intensity monitors measuring the total UV output. Each irradiation chamber contains one 2.5-kW mercury vapor, medium-pressure arc tube, generating UV radiation at 253.7 nm. 

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