Control endogenous

Verotta, D., Concepts, properties, and applications of linear systems to describe distribution, identify input, and control endogenous substances and drugs in biological systems, Crit. Rev. Biomed. Eng., 24, 73-139, 1996. 

The presence of feedback systems in endocrine function is important from a pharmacologic perspective. Drugs can be administered that act through the intrinsic feedback loops to control endogenous hormone production. A primary example is the use of oral contraceptives, when exogenous estrogen and proges-... 

In mnrine studies, quinolones have been effective in controlling endogenous gramnegative systemic infections following radiation. Qninolones are also effective in preventing endogenous Klebsiella and Psendomonas infections. In addition, penicillin snpplementation has prevented treatment failnres in cancer patients with treatment-induced neutropenia (2). 

An attractive possibility is that stimuli which affect plant growth and development act on the systems which control endogenous amounts of lAA, and thus the stimulus is transduced into the appropriate growth or developmental response. The tropic responses and the development of secondary vascular tissue are examples of situations where careful measurement of hormone levels have shown that the levels of lAA are playing an important part in bringing about a specific response. 

Controlling Endogenous Signaling by Modulating the PSC Aggregate or Niche Size... 

The PBRis distinct from the central BZ receptor although both can be present in the same tissues in differing ratios. PBRs are predominately localized on the outer mitochondrial membrane and are thus intracellular BZ recognition sites. The PBR is composed of three subunits an 18,000 mol wt subunit that binds isoquinoline carboxamide derivatives a 30,000 mol wt subunit that binds BZs and a 32,000 mol wt voltage-dependent anion channel subunit. The porphyrins may be endogenous ligands for the PBR. PBRs are involved in the control of cell proliferation and differentiation and steroidogenesis. 

The method was validated in accordance to the guidelines of the international conference on harmonization (ICH). Data with respect to accuracy, within- and between run precision, recovery, detection and quantitation limits were reported and found to be within the accepted international criteria. Neither endogeneous substances nor the commonly used dmgs were found to interfere with the retention times of the analytes. Standard solutions of the dmg and quality control preparations at high and low level concentrations were demonstrated to be stable at room temperature and/or -20°C for long and short periods of time. 

The basis for believing the pharmacological intervention can be a major approach to the treatment of disease is the fact that the body generally functions in response to chemicals. Table 1.1 shows partial lists of hormones and neuro transmitters in the body. Many more endogenous chemicals are involved in normal physiological function. The fact that so many physiological processes are controlled by chemicals provides... 

Some endogenous chemicals controlling normal physiological function. 

The fibrinolytic reactions are controlled by endogenous blood plasma inhibitors as well [3]. 

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