Contract research proteins

Studies on muscle contraction carried out between 1930 and 1960 heralded the modem era of research on cytoskeletal stmctures. Actin and myosin were identified as the major contractile proteins of muscle, and detailed electron microscopic studies on sarcomeres by H.E. Huxley and associates in the 1950s produced the concept of the sliding filament model, which remains the keystone to an understanding of the molecular mechanisms responsible for cytoskeletal motility. 

Bio-Research Products Inc., was founded in 1975, and specialized in the isolation, purification and characterization of enzymes and proteins. The company is well known for its production of wheat germ phosphoenolpyruvate carboxylase (PEPC). Currently, it is involved in finished goods and raw material production, through a biomedical contract. Bio-Research Products runs custom services on enzymes, proteins production, diagnostic assays, and other goods for industry, governments, or academia. Bio-Research Products, Inc. also markets a number of enzymes and associated products, and carries out custom synthesis projects. 

Some of the protein data presented here are outputs from the EU FP6 proj ect SAFE FOODS (Contract No. Food-CT-2004-506446), which is cordially acknowledged. The work of P JW on potato mineral composition is supported by the Scottish Government Rural and Environmental Research and Analysis Directorate (RERAD). 

Benschop HP, Noort D, van der Schans GV, de Jong LPA. Diagnosis and dosimetry of exposure to sulfur mustard development of standard operating procedures further exploratory research on protein adducts. Final report for contract DAMD17-97-2-7002, ADA381035, 2000. 

The current research priorities include elucidation of the in vivo function of proteins such as CD and CP that need not involve cross-bridge cycling, and resolving the physiological relevance of the experimental situations in which LC20 phosphorylation does not explain contraction. Another potentially fertile topic is identification of mechanisms that modulate MLCK and MLCP activities and, of equal importance, establishing their in vivo significance. 

The exact mechanism by which the protein in muscle fiber contracts and extends has been the subject of much research but it is still far from clear. As might be expected, some attempts have been made to see... 

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