Continuous chromatographic separation

The slowly rising foam in a tall column can Be employed as the sorbent for continuous chromatographic separations [Talman and Rubin, Sep. Sci., 11, 509 (1976)]. Low gas rates are also employed in short columns to produce the scumlike froth of batch-operated ion flotation, microflotation, and precipitate flotation. 

Pais L. S., Loureiro J. M., Rodrigues A. E. (1997b) Modeling, Simulation and Operation of a Simulated Moving Bed for Continuous Chromatographic Separation of l,l -bi-2-naphthol Enantiomers, J. Chromatogr. A 769 25-35. 

Hypersorption A continuous chromatographic separation process using a moving bed. Invented in 1919 by F. D. Soddy (famed for his work on isotopes) at Oxford and developed commercially for petroleum refinery separations by the Union Oil Company of California in 1946. Six plants were built in the late 1940s, using activated carbon as the adsorbent. The process was abandoned because attrition of the bed particles proved uneconomic. 

Pedeferri, M. Petrozzi, S. Mazzotti, M. Morbidelli, M., Design and Operation of a HPLC-SMB Laboratory Unit for Continuous Chromatographic Separations. CHIMICA OGGI 1998 (March/April), 38. 

Pais, L., Loureiro, J., Rodrigues, A. Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of l,l-bi-2-naphthol enantiomers,... 

Saska, M Clarke, S. J., Wu, M. D., Iqbal, K. Applications of continuous chromatographic separation in the sugar industry, Part I. Glu-cose/fructose equilibria on Dowex Monosphere 99 Ca resin at high sugar concentrations, Int. Sugar J., 1991, 93, 1115. 

For the 4-subinterval 5-column Varicol process, the optimum is foimd along line FGLM. The multiobjective optimization effectively shows the variability of the decision variables and operation conditions of the continuous chromatographic separation. The 5-column Varicol process offers higher purities than the equivalent 5-column conventional SMB, using the same amount of stationary phase. 

Navarro, A. Carmel, H. Rigal, L. Phemius, P. Continuous chromatographic separation process simulated moving bed allowing simultaneous withdrawal of three fractions. J. Chromatogr. A, 1996, 770, 39-50. 

Figure 43. Moving port chromatographic column with four zones for continuous chromatographic separation. ...

Graphite furnace AAS would provide trace level sensitivity, however, GF-AAS instruments are not designed for continuous operation. This prevents their use as on-line detectors for continuous chromatographic separation. 

The search for a cost-effective synthetic method for the production of (4S)-tetralone 4, the intermediate on the pathway to sertraline, was shifted to technology that is still new to the pharmaceutical industry - continuous chromatographic separation... 

It is useful to recall how multicomponent separation is achieved, for example in electrophoresis, before we focus on continuous chromatographic separation. As illustrated in Figure 7.3.1 in a thin-film continuous-flow electrophoresis separator, the feed mixture of proteins introduced at the feed point location x = jco) moves with the buffer in the z-direction at buffer velocity v. However, due to the electrical force in the perpendicular direction (jr-coordinate). 

We will now try to understand different device configurations for continuous chromatographic separation. Consider a regular packed column with a sample of a multicomponent feed injected at z = 0, the mobile phase moving with an interstitial fluid velocity and equilibrium... 

Figure 8.3.4 illustrates the principle of such a continuous chromatographic separation operation. In the device... 

Figure 8.3.4. Continuous chromatographic separation of a four-component feed-gas mixture in a magnetically stabilized fluidized bed moving in the z-direction with carrier gas and feed-gas mixture introduced via crossflow in the y-direction. (After Siegell et al. (1986).)...

Production of crystallized fructose is rather problematic because of the high solubility of f Starting from high-fructose syrups or from - invert sugar, enrichment of f. is performed by cyclical or continuous chromatographic separation from glucose. F. contents of 85-96% and 90% of d.s. are necessary for crystallization. The process can be either batch or continuous. 

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