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Consensus sequence recognized structure

In contrast to Myc, Max can form homodimers that bind tightly to DNA. These homodimers recognize the same consensus sequence as members of the b/HLH family, 5 -CANNTG-3. The three-dimensional structure of the b/HLH/zip domain of Max complexed with a DNA fragment containing the sequence 5 -CACGTG-3 has been determined by the group of Stephen... [Pg.199]

The Ser, Thr, or T)yr residues that are phosphorylated in regulated proteins occur within common structural motifs, called consensus sequences, that are recognized by specific protein kinases (Table 6-10). Some kinases are basophilic, preferring to phosphorylate a residue having basic neighbors others have different substrate preferences, such as for a residue near a Pro residue. [Pg.230]

The recruited proteins may have quite different functions, but their structures often have in common that they contain consensus sequences, 50-100 amino acids long, although the adjacent regions may be quite different. Among sequences recognizing phosphot5Tosyls are the Src homology domain, SH2, and the PTBs. [Pg.33]

M. Tonelli, E. Ragg, A.M. Bianucci, K. Lesiak and T.L. James. Nuclear magnetic resonance structure of d(GCATATGATAG). d(CTATCATATGC) a consensus sequence for promoters recognized by sigma K RNA polymerase. Biochemistry 37... [Pg.406]

Kor a and Ozols (1988) and Ozols (1989) established the primary structures of two microsomal esterases purified from rabbit liver and designated them as 60-kDa esterase form 1 and form 2. These two forms of CarbE have the consensus sequence of the ER retention tetra-peptide (HTEL or HIEL in the one-letter code) which recognized with the luminal side of the KDEL receptor, Robbi el al (1990) reported cDNA cloning of rat liver pi 6.1 esterase (ES-10) and pi 5.5 esterase (ES-3, egasyn). This was the... [Pg.223]

The helical basic region of Max binds to the major groove of DNA in the same manner as MyoD (see Figures 10.26 and 10.28). The DNA structure is essentially that of B-DNA with minor distortions as in the MyoD complex. Both Max and MyoD recognize the same consensus half-site DNA sequence 5 -CAC-3 ... [Pg.201]


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Consensus sequence

Consensus sequence recognized

Sequence-structure

Sequencing structure

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