Conjunctivitis allergic drug reaction

This drag lessens the allergic response of the organism caused by histamine. Tripelennamine is used for allergic symptoms, rhinitis, conjunctivitis, and for allergic and anaphylactic reactions. Synonyms of this drug are pelanin and pyribenzamine. 

Ocular complications are rare with systemic use of this class of drugs. Lid edema, conjunctivitis, chemosis, anterior uveitis, and scleral reactions have been reported with high-dose administration of sulfenilamide. The observed reactions appear to be analogous to systemic hypersensitivity reactions, such as urticaria and edema, seen in some patients who are allergic to sulfonamides. Several cases of Stevens-Johnson syndrome have been reported in patients of Japanese or Korean descent who were given oral metha-zolamide, a sulfonamide used to decrease lOP. Stevens-Johnson syndrome tends to show acute ocular involvement in 69% of affected individuals.This is stratified into mild ocular involvement in 40%, moderate in 25%, and severe in 4%. Late complications can occin and are usually in the form of severe ocular surfece disease and trichiasis. 

Type I reactions are IgE mediated and cause manifestations of allergic symptoms due to the release of immune mediators such as histamine or leukotrienes. These reactions typically occur within minutes of drug exposure and may manifest as generalized prurituS/ urticaria/ angioedema/ anaphylaxiS/ rhinitiS/ or conjunctivitis (21). Anaphylaxis can result from exposure to any antigen (e.g./ penicillin) and may be fatal in the absence of prompt medical intervention. 

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