Conjugated linoleic acid anticarcinogenic activity

Conjugated linoleic acid (CLA) is a collective term for positional (9,11 and 10,12) and geometric (trans,cis cisjrans cis,cis and trarts,tram) isomers of octadecadienoic acid (Cl8 2) with a conjugated double bond. Synthetic CLA, prepared from linoleic acid by alkaline isomerization, exhibits potent anticarcinogenic activities in several carcinogen-induced animal models 1-4) and cytotoxicities for several cancer cell lines (5-5). Other biological activities, such as immune stimulation (P), body fat reduction 10,11 modulation of cholesterol content 12) and growth stimulation 13) were also reported. 

Animal tissues, absorption and deposition of conjugated dienoic isomers of linoleic acid, 263-268 Anosmias, flavor chemicals, 19,2U Anticarcinogenic activity, conjugated dienoic derivatives of linoleic acid, 268-269... 

Bovine milk fat contains a number of unique fatty acids, some of which have been linked to specific health-promoting properties. Modifying the chanical composition and structure of the milk can further enhance these properties. One fatty add found in relative abundance in milk fat is conjugated linoleic add (CLA), which continues to receive considerable attention because of its assodation with such potential beneficial effects on health as anticarcinogenic, antiatherogenic, and antidiabetogenic activities [see (1) for review]. Recent human studies have demonstrated the link between dietary CLA intakes and risk of breast cancer in postmenopausal women (2). 

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