Conformer, active

Hruby VJ, Agnes RS. Conformation-activity relationships of opioid peptides with selective activities at opioid receptors. Biopolymers (Peptide Sci) 1999 51 391-410. 

Wilkes BC, Schiller PW. Conformation-activity relationships of cyclic dermorphin analogues. Biopolymers 1990 29 89-95. 

We have extensively Investigated the conformation-activity relationships of oxytocin (H-C s-Tyr-Ile-Gln-Asn-C s-Pro-Leu-Gly-NH2) antagonists based on the antagonist [Pen ]-oxytocln (. . 2) ... 

Brandt, W., Barth, A., Holtje, H.D. A new consistent model explaining structure (conformation)-activity relationships of opiates with mu-selectivity, Drug Des. Discov. 1993, 10, 257-283. 

Regulation of the rate of pyrimidine nucleotide synthesis in bacteria occurs in large part through aspartate transcarbamoylase (ATCase), which catalyzes the first reaction in the sequence and is inhibited by CTP, the end product of the sequence (Fig. 22-36). The bacterial ATCase molecule consists of six catalytic subunits and six regulatory subunits (see Fig. 6-27). The catalytic subunits bind the substrate molecules, and the allosteric subunits bind the allosteric inhibitor, CTP. The entire ATCase molecule, as well as its subunits, exists in two conformations, active and inactive. When CTP is... 

Belleau and collaborators (30-32) have recently pointed out that one aspect of conformation-activity relationships which has escaped attention concerns the importance of stereoelectronic effects. More specifically, they have proposed that stereoelectronic effects about the basic nitrogen of morphin-ans as opposed to stereoisomerism about chiral carbons play an important role at the analgesic receptor level. They have presented concrete evidence that the relative spatial orientation of the nitrogen lone pair in morphin-ans is of critical importance for productive interaction with the opiate receptors. 

The receptors for these hormones are typical seven-transmembrane-domain serpentine peptides (see Chapter 2 Drug Receptors Pharmacodynamics). Each hormone acts as a ligand within a receptor pocket, inducing conformational activating changes in the receptor. The conformational changes in the receptor s intracellular third loop and carboxyl terminal tail activate an adjacent intracellular G protein. The Gm protein is associated with the receptors for GnRH and TRH, G with the dopamine receptor, and Gs protein with the receptors for the other hormones listed above. 

Sealfon SC, Chi L, Ebersole BJ, et al. Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor. J Biol Chem 1995 270 16,683-16,688. 

Hibert MF, Hoffmann R, Miller RC, Carr AA. Conformation-activity relationship study of 5-HTj receptor antagonists and a definition of a model for this receptor site. J Med Chem 1990 33(6) 1594-1600. 

Physical Properties. For the rigid methamphet-amine analogs NM-X and NM-N to be good models for pharmacological studies and of any value in the determination of conformation-activity relationships, it is necessary that they show similar physical properties to the parent. Two properties of importance are the basicity and the lipophilicity,for these properties will greatly influence transport to the various sites of action. 

Thus, comparison of the charge distribution calculated by CNDO/2, the pKa values and the partition coefficients shows that both NM-X and NM-N are excellent models for a study of conformation-activity relationships of methamphetamine. 

Conclusion. Thus, conformation-activity relationships have clearly been found using the endo-and exo-2-amino (or 2-methylamino) isomers of benzo-bicyclo[2.2.2]octene as models for the gauche and extended conformations of amphetamine and methamphetamine. Further work to extend these studies into substituted amphetamines and catecholamines is in... 

CONFORMATION-ACTIVITY RELATIONSHIPS OF SOME CHOLINERGIC AGONISTS... 

Conformation-Activity Relationships of Some Cholinergic Agonists... 

Chemical modification via thioamide intermediates and conformation-activity relationships of an antitumor bicyclic hexapeptide 04YGK993. 

D. C., Zhou.Y., Conformation-activity relationships in polyketide natural products a new perspective on the rational... 

---