Solid State Conformations of Drugs and Biologically Active Molecules

2 Solid State Conformations of Drugs and Biologically Active Molecules 

Dynamics in the solid state include processes of an intramolecular proton transfer the tautomerism of porphyrin [10] or the intramolecular proton transfer in cyclic AW-bisaryl formamidine dimers [11] was studied by means of CP MAS NMR. 

Reorientation of molecular fragments, such as the aromatic ring (as in penicillins, see below) can be investigated in the solid state the processes are followed by variable-temperature studies. In the solid-state spectra the changes of line shapes (from separate 

Interesting conformational effects were observed for solid arylpiperazine derivatives. The CP MAS spectra of the buspirone analog 3a,4,7,7a-tetrahydro-2- 4-[4-(2-quinolinyl)-1 -piperazynyl]butyl -4,7-ethane-1 H-isoindole-1,3(2H)-dione hydrochloride and 

Solid-state NMR studies were performed on various biomolecules nucleosides [13] d,l-methionine [14] and selenomethionine [15], aminoacids and peptides [16], [17], [18], [19] natural and synthetic melanins [20], flavonoids [8], p-carotene [21], a- and P-D-glucose [22], lactose [23], lactulose [24], sugar derivatives of tocopherol [25] and numerous other sugar derivatives [26]. 

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