Concanavalin polysaccharide-binding sites

Removal of polysaccharide contaminants from preparations of DNA by affinity chromatography Separation of membrane glycoproteins from rat-brain synaptic vesicles by affinity chromatography Studies of the interactions of the carbohydrate-binding sites on concanavalin A with adipocyte receptors... 

Poly-amido-saccharides (PAS) (Figure 2.9) are synthetic carbohydrates that can mimic natural polysaccharides as they can bind lectin concanavalin A (ConA) at the same site as natural carbohydrates. PAS are synthesised via anionic ROP of a P-lactam sugar monomer. In PAS, the pyranose rings are linked through the 1- and 2-positions by an amide with a-stereochemistry. P-lactam sugar is synthesised from benzyl-protected D-glucal [56]. 

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