Compounds methoxychlor-related

A very similar phenomenon was observed for methoxychlor related compounds. Also the more polar metabolites 4,4 -dimethoxy-benzophenone and 2,2-bis(4-methoxyphenyl)acetic acid became most abundant within the bound organic fraction. 

Furthermore, numerous methoxychlor-related compounds were detected not only in the extracts but also in parts of the hydrolysis products. 

Insecticidal activity of DDT and related compounds is due to their neuroexcitatory effect, the mechanism of which is very similar to that of pyrethroids 75). Using a number of analogs of DDT (34), DDD (35), and prolan (36), p,p -substituents of which are modified variously as well as those of methoxychlor (37), the trichloro-... 

Estimate the Ki0Vi values at 25°C of the following compounds based on the experimental Ki0Vi values of the indicated structurally related compounds (a) benzoic acid dimethylaminoethyl ester from benzoic acid ethyl ester (log Kiaw = 2.64), (b) the insecticide methoxychlor from DDT (log Ki0Vi = 6.20), (c) the insecticide fenthion from parathion [log Kiow = 3.83, see 111. Ex. 7.2, Answer (d)], and (d) the hormone estradiol from testosterone [log Ki0Vi = 3.32, see 111. Ex. 7.2, Answer (e)]. 

The physical properties of these compounds are somewhat different from prolan, DDT, methoxychlor, perthane, and other related chemicals. Water solubility and polarity are considerably... 

Furthermore as a result of industrial emissions the Teltow Canal sediments are highly polluted by the pesticides DDT and methoxychlor, accompanied by several metabolites (Schwarzbauer et al. 2001). Accordingly, numerous DDT-related compounds were identified in the hydrolysis extracts including DDE 6, DDMU 7, DDNU 8 and DDM 9. Highest concentrations were observed for DDA 10 and DBP IT, the more polar degradation products of DDT. 

Further investigations revealed not only the presence of DDT and its metabolites in Teltow Canal sediments but also the occurrence of 2,4 and 4,4 -methoxychlor (MDT) at elevated concentrations (up to 1100 pg/kg) (22). As methoxychlor is structurally related to DDT, MDT-related compounds were also included in the quantitative analyses (see Tab. 6). We detected MDT, MDD, MDE, MDB and MDA in the extracts and partly in the hydrolysis product mixtures of all four sediment samples. The total amounts ranged between 600 and 8000 pg/kg in the extracts and between 1200 and 6000 pg/kg after application of the hydrolysis procedure. In degradation products after BBr3-treatment and RuC -oxidation no MDT-related substances were analysed likely due to the lower concentration level as compared to the DDT-related compounds. 

Tab. 6 Methoxychlor (MDT) related compounds quantified in extracts and hydrolysed residues of Teltow Canal sediment samples (concentrations are given in pg/kg dry matter).

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