Discovery compounds

Z)- and (ii)-diazocyanides 146 Disazo compounds, see Bisazo compounds Discovery and development of scientific... 

Gusev, A. L, Development and Applications of LC/MS for High Throughput Analytical Screening for Accelerated" Compound Discovery, American Society for Mass Spectrometry 2001 Conference Abstract, Chicago, ILL, USA, 2001. 

The previous two methods of lead compound discovery exploited naturally occurring endogenous or exogenous compounds. However, of the approximately 10 small organic molecules that could theoretically exist in our world (10 of which are druglike molecules), many would be purely synthetic substances that do not occur naturally. The lead compound discovery methods discussed in sections 3.2.5 and 3.2.6 afford an... 

This is particularly true if one is pursuing lead compound discovery by high throughput screening of millions of compounds. 

The existing techniques used to screen conventional chemicals, however, may not be adequate to support the discovery of new biopesticides, particularly biochemical pesticides. Non-traditional approaches for new compound discovery may be needed. The potential for the discovery of new naturally occurring... 

R. B. McAlister, K. Reitz, G. Kang, R. Nakatsu, T. Green, C. Library-Based Lead Compound Discovery Antioxidants by an Analogous Synthe-sis Deconvolutive Assay Strategy, J. Org. Chem. 1994, 59, 5862. (e) Moon, H.-S. Schore, N. E. Kurth, M. J. A Polymer-Supported C2-Symmetric Chiral Auxiliary Preparation of Non-Racemic 3,5-Disubstituted-y-Butyro-... 

Kurth MJ, Ahlberg Randall LA, Chen C, Melander C, Miller R, Library-based lead compound discovery antioxidants by an analogous synthesis deconvolu-tive assay strategy, J. Org. Chem., 59 5862-5864, 1994. 

Nowadays, HTS has the potential to revolutionize not only compound discovery but also the development phase. By automating routine processes and miniaturizing assay format, HTS facilities can screen as many as 10,000 samples a day, in comparison with the hundreds per week in the 1980s. This factor alone greatly accelerates the discovery process. 

With a compound discovery method in place that achieves high potency and specificity, all that remains for aptamers to have utility as drugs would be stability, pharmacokinetics, toxicity, and low immunogenicity of aptamers in vivo. Because the literature was clear about the major human plasma endonucleases that destroy RNA molecules, one early event in the NeXstar... 

Microbial sources other than Streptomyces spp. have also provided highly interesting and structurally diverse compounds. Discovery of epothilones from myxobacterial strains by a German group (82) and the Merck group (83, 84) constitute a... 

Organizing Bioactive Compound Discovery in Target Families... 

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