High Throughput Analytical

Since only a small fraction of the interfering material reaches the second column and Subsequently the detector, the next analysis can start after the analyte has been transferred to column 2. This provides a high throughput (about 7 samples per hour). 

Even with the development of high-throughput analytical equipment, the discovery phase still requires a significant investment of time and resources. Future trends will likely focus on increasing the number of available dehydrogenases and cutting the time and effort needed to screen them. 

Data systems, more broadly known as Laboratory Information Management Systems, are in almost universal use in laboratories, allowing the collection of mass data required by parallel and high-throughput analytical... 

The application of combinatorial principles in chemical synthesis, particularly in the search for active substances, requires analytical methods with high throughput (von dem Bussche-Hunnefeld et al. [1997]). Screening techniques can be used to analyse a large number of test samples in a short... 

Some Thoughts about High-throughput Analytical Chemistry... 

In a direct immunoassay the immobilized antibody binds to the corresponding antigen. The competitive immunoassay relies upon the competition of the analyte with a labelled analyte for antibody binding. These formats are widely used for high throughput affinity arrays. A sandwich immunoassay is based on the trapping or capture of the analyte by another antibody. In ELISA (enzyme linked immunosorbent assays) the second antibody is conjugated with an enzyme. The bound enzyme labelled antibody is detected by its ability to break down its substrate to a colored product. 

The relative simplicity of the sensor setup allows them to be implemented into portable automated devices or bed-side analyzers (Fig. 4.2), which are easily installed at patient beds, eliminating the time-consuming laboratory analyses. On the other hand, modem high throughput clinical analyzers may process more than 1000 samples per hour and simultaneously determine dozens of analytes, using a handful of analytical methods. Blood electrolyte analysis, however, remains one of the most important in... 

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