Composition of articular cartilage

Both the collagen fiber orientation and the overall composition of articular cartilage are heterogeneous in the axial direction, and thus contribute to the distinction of three zones of articular cartilage ... 

The remarkable mechanical properties of articular cartilage result from the structure of collagen and proteoglycans, and from the properties of the fibrous composite formed by the interactions of collagen and proteoglycans in intercellular matrix. 

Sophia Fox, A.J., Bedi, A., Rodeo, S.A., 2009. The basic science of articular cartilage structure, composition, and function. Sports Health 1, 461—468. 

Poole, A.R., Kojima, T., Yasuda, T., Mwale, F., Kobayashi, M., Laverty, S., 2001. Composition and structure of articular cartilage—a template for tissue repair. Clinical Orthopaedics and Related Research 391, S26-4S33. 

Nguyen, L.H., Kudva, A.K., Guckert, N.L., Linse, K.D., Roy, K., 2011a. Unique biomaterial compositions direct bone marrow stem cells into specific chondrocytic phenotypes corresponding to the varions zones of articular cartilage. Biomaterials 32,1327-1338. 

The latter issue was addressed more recently by Hamilton et al. who developed a trilayer composite consisting of CPP, articular cartilage (CEP), and NP tissue [125]. By sequential seeding of chondrocytes onto the CPP surface followed 2 weeks later by seeding NP cells onto the matrix produced by the chondrocytes, the authors were able to form a tissue composite construct. Although it appeared that the NP cells were able to maintain a rounded morphology, the interfacial shear load required to... 

In the biomedical area, SPHs and SPH composites can be used to make various biomedical devices, such as artificial pancreas, artificial cornea, and artihcial skin, articular cartilage, soft tissue substitutes, cell growth substrates in tissue engineering, burn dressings, surgical augmentation of the female breast, or hemoperfusion in blood detoxification and in the treatment of uremia. 

Articular cartilage has to sustain changes of chemical composition of the electrolyte and mechanical loads. Its overall bearing capacity is believed to... 

Chemical composition and sedimentation coefficients (s 0) of proteoglycan monomer fractions from bovine articular cartilage (36). Column 1 shows the amino acid composition of the hyaluronic acid-binding region of proteoglycan monomer core protein, isolated... 

Some authors (Nixon et al. 1991 Adcocks et al. 2002) also use bovine nasal septum as cartilage source, but the convenient homogeneity and mass of this tissue is outweighed by a matrix composition and biomechanical properties clearly distinct from articular cartilage. 

Composition and organization of connective tissues (with special reference to articular cartilage)... 

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