Detoxification, blood

In the biomedical area, SPHs and SPH composites can be used to make various biomedical devices, such as artificial pancreas, artificial cornea, and artihcial skin, articular cartilage, soft tissue substitutes, cell growth substrates in tissue engineering, burn dressings, surgical augmentation of the female breast, or hemoperfusion in blood detoxification and in the treatment of uremia. 

The described sorbent modification technique by using neutral anolite solution improves the efficiency of blood detoxification and improves treatment results in... 

The described sorbent modification techniqne by nsing nentral anolite solntion improves the efficiency of blood detoxification by hemosorption. It has a stimulating effect and improves treatment resnlts in patients with mnltiple organ failure. 

Keywords Absorptive capacity sorption efficiency erythrocyte toxicity test (osmotic) heme protein restored-iron iron-silica iron-carbon surface modification blood detoxification barbiturates bilirubin blood purification. 

To use a more sophisticated example, we can look to the products of the neem tree (Azadirzchta indica), a tropical plant that is known for its pesticidal properties. The seed of this tree is abundant with limonoids and simple terpenoids that are responsible for its biological activity. One particular limonoid found in the seed is Azadirachtin (2.134). The bioactivity of Azadirachtin potentially leads to a wide range of applications in herbal medicine and healthcare products for the treatment of malaria and tuberculosis and in anti-worm, clotting, and blood-detoxification preparations. These uses of Azadirachtin as a biopesticide or herbal medicine is limited due to solubility constraints in water and its instability as a result of its propensity to undergo complicated, irreversible rearrangements under acidic, basic and photolytic conditions. Consequently, there has been much research in the structural modification of Azadirachtin to overcome its solubility constraints to increase stability. This process normally involves many protection and deprotection synthetic steps and chromatographic separations. 

A knowledge of physiology and pharmacokinetics is needed (Fanis et al. 1993 Monteiro and Furness 2001). Levels of mercuiy normally vary among internal tissues, and the time to equilibrate within each tissue varies. For example, blood mercury levels normally reflect veiy recent exposure, while brain and liver levels reflect longer-term exposure. Tissue-specific mechanisms of detoxification and seqnestration, among other processes, must be understood to define the bioactive moiety in observed tissue bmdens before a clear expression of toxicity can be derived (Woodetal. 1997). 

H and HD are blister and alkylating agents, producing cytotoxic action on the hematopoietic (blood-forming) tissues. The rate of detoxification of H and... 

HD is a vesicant (blister agent) and alkylating agent producing cytotoxic action on the hematopoietic (blood-forming) tissues which are especially sensitive. The rate of detoxification of HD in the body is very slow, and repeated exposures produce a cumulative effect. It causes blisters, irritates the eyes, and it is toxic when inhaled. HD has been determined to be a human carcinogen by the International Agency for Research on Cancer. 

Alterative. Alteratives increase blood flow to the tissues, improving metabolism and detoxification. Elder s alterative action helps to improve many skin afflictions including boils, eczema, acne and erysipelas. Elder improves the secretions involved with many bodily functions. Parts used flowers, berries, young shoots. 

Pitcher MCL, Beatty ER, Harris RM, et al. 1998. Sulfur metabolism in ulcerative colitis investigation of detoxification enzymes in peripheral blood. Dig Dis Sci 43 2080-2085. 

The liver is the dominant organ in the detoxification process. The detoxification occurs by biotransformation, in which the chemical agents are transformed by reaction into either harmless or less harmful substances. Biotransformation reactions can also occur in the blood, intestinal tract wall, skin, kidneys, and other organs. 

---