Component collection, microchannel

Besides that, compressive force can be manipulated to facilitate cell lysis and collect their cellular components for later cell-based assay. Similarly, Wang et al. fabricated a micromechanical stimulator fliat is capable of providing controlled compressive or tensile strain to the cultured cells in vitro (Fig. 4). Experimental characterization of its PDMS membrane deformation showed that the microdevice can provide —6 % compressive to 25 % tensile radial strain to the cultured cells within the membrane center [6], which allowed simultaneous investigation of both mechanical strains on the same cells. Zhou et al. developed a microchip platform with microchannels that resembles the mechanical environment of small blood vessels in vivo (Fig. 5). They demonstrated that the deformation of the membrane by hydraulic pressure induced cyclic circumferential strains on the adhered mesenchymal stem cells and thus caused significant stmctural and biochemical changes to the cells [7]. 

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