Binding complex

The GroEL-GroES complex binds and releases newly synthesized polypeptides in an ATP-dependent cycle... 

GroES closes off one end of the GroEL cylinder The GroEL-GroES complex binds and... 

Steroid hormones act in a different manner from most hormones we have considered. In many cases, they do not bind to plasma membrane receptors, but rather pass easily across the plasma membrane. Steroids may bind directly to receptors in the nucleus or may bind to cytosolic steroid hormone receptors, which then enter the nucleus. In the nucleus, the hormone-receptor complex binds directly to specific nucleotide sequences in DNA, increasing transcription of DNA to RNA (Chapters 31 and 34). 

COMPLEX BINDING PHENOMENA AGONIST AFFINITY FROM BINDING CURVES... 

FIGURE 4.15 Complex binding curves for agonists in G-protein unlimited receptor systems. 

Agonists can produce complex binding profiles due to the formation of different protein species (i.e., ternary complexes with G-proteins). The extent of this phenomenon is related to the magnitude of agonist efficacy and can be used to quantify efficacy. 

FXa complexes bind to and neutralize tissue factor/ FVIIa complexes, the key starting point of the extrinsic clotting cascade (see earlier) (Fig. 7). Heparin is able to enhance this reaction by direct binding to the complex and by releasing TFPI from the unaltered vessel wall, which then can access the TF-exposing surface. 

Class IIHLA molecules are expressed on the surface of antigen-presenting cells. They play a key role in presentation of processed linear peptide antigens of at least nine amino acids to T cells. Antigen is bound to the HLA antigen binding cleft formed by the a and 3 chains of the HLA class II molecule. This tri-molecular HLA-antigen complex binds in turn to the variable portion of the T-cell receptor. 

Macropolycyclic ligands, 2,942 classification, 2,917 metal complexes binding sites, 2, 922 cavity size, 2,924 chirality, 2, 924 conformation, 2,923 dimensionality, 2, 924 electronic effects, 2, 922 shaping groups, 2,923 structural effects, 2,922 molecular cation complexes, 2,947 molecular neutral complexes, 2,952 multidentate, 2,915-953 nomenclature, 2,920 Macro tetrolide actins metal complexes, 2,973 Macrotricycles anionic complexes, 2,951 cylindrical... 

Miller LG, Greenblatt DJ, Roy RB, et al Chronic benzodiazepine administration, II discontinuation syndrome is associated with upregulation of gamma-aminobutyric acid receptor complex binding and function. J Pharmacol Exp Ther 246 177-182, 1988b... 

The first step in this process involves the binding of GTP by eIF-2. This binary complex then binds to met-tRNAf a tRNA specifically involved in binding to the initiation codon AUG. (There are two tRNAs for methionine. One specifies methionine for the initiator codon, the other for internal methionines. Each has a unique nucleotide sequence.) This ternary complex binds to the 40S ribosomal subunit to form the 43S preinitiation complex, which is stabilized by association with eIF-3 and elF-lA. 

In nonpolar solvents, for example alcohols, the hydroxyls of the support can also be used to anchor alkoxy compounds to the surface in a condensation reaction, in which one alkoxy ligand reacts with the proton of the surface OH to give the corresponding alcohol, and the complex binds to the support. An example is the anchoring of zirconium ethoxide, Zr(OC2H5)4, to silica by means of the reaction... 

Fig. 1 Immune complex binding activity of pectic polysaccharides (Reproduced with permission from reference 6. copyright 1994 Carbohydrate polymer).

Fig. 2 Inrnume complex binding enhancing activity of Carbohydrate fragments obtained by endo-polygalacturonase digestion...

Fig. 3 Scatchard analysis of inmiune complex binding to the macrophages incubated with bupleuran 2IIb...

Fig. 5 Effect of GL-4IIb2 and periodate oxdization product on FcR mediated immune complex binding to macrophages...

Accordingly, TEM investigations confirmed the NPs formation in Pt-catalysed hydrosilylation from a solution of [PtCl2(cod)]. The particles formed in situ showed a mean size of 2.3 nm. Moreover, XPS (X-ray Photoemission Spectrometry) analysis confirmed that the colloid characteristics are distinct from bulk metal and monometallic complex (binding energy for Pt bulk metal is 71.0 eV for [PtCl2(cod)], 72.45 eV and for Pt colloid, 72.24eV) [12]. 

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