GroEL/GroES/ 7 complex

The GroEL-GroES complex binds and releases newly synthesized polypeptides in an ATP-dependent cycle... [Pg.102]

How does the GroEL-GroES complex function as a chaperone to assist protein folding Although several aspects of the mechanism are not clear, the main features of the functional cycle are known. The first step is the... [Pg.102]

Chen, S. et al. Eocation of a folding protein and shape changes in GroEL-GroES complexes imaged by cryo-electron microscopy. Nature 371 261-264, 1994. [Pg.119]

GroES closes off one end of the GroEL cylinder The GroEL-GroES complex binds and... [Pg.414]

Expanded GroEL-GroES complex with enclosed folding polypeptide0... [Pg.339]

The reaction cycle starts with a GroEL-GroES complex containing ADP bound to the cis ring (Fig. 2, step 1). The... [Pg.210]

Farr GW, Fenton WA, Rospert S, Horwich AR. Folding with and without encapsulation by cis and trans-only GroEL-GroES complexes. EMBO J 2001 22 3220-3230. [Pg.213]

Chen, S., Roseman, A. M., Hunter, A. S., Wood, S. P., Burston, S. G., Ranson, N. A., Clarke, A. R., and Saibil, H. R. (1994). Location of a folding protein and shape changes in GroEL-GroES complexes imaged by cryo-electron microscopy. Nature 371, 261-264. [Pg.381]

N. A. Ranson, D. K. Clare, G. W. Farr, D. Houldershaw, A. L. Horwich and H. R. Saibil, Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes. Nat. Struct. Mol. Biol., 2006,13, 147-152 (fitted coordinates, Cryo-EM) (pdbs 2c7c 2c7d). [Pg.549]

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